- Systematic Review
- Open Access
Proximal femoral replacement for non-neoplastic conditions: a systematic review on current outcomes
Journal of Orthopaedics and Traumatology volume 23, Article number: 18 (2022)
Proximal femoral replacement (PFR) is a well-established treatment for neoplasia of the proximal femur. The use of this surgical technique for non-neoplastic conditions has increased over the years. We carried out a systematic review of the literature to study the indications, complications, and functional results when PFR is used for non-neoplastic conditions. Twenty-seven studies were included in the review with a total of 828 PFRs with a mean follow-up of 50 months (range 1–225 months). The main indications were infection (28%), periprosthetic fracture (27%), aseptic loosening (22%), and fracture (16%). The rate of reoperation was 20.3% overall. The overall revision rate was 15.4%. The main complications were dislocation (10.2%) and infection (7.3%). After 2010, the rates of reoperation (25.5% versus 18.2%), loosening (9.4% versus 3.2%), and dislocation (15.7% versus 7.9%) were lower than before 2010. The 30-day mortality ranged from 0% to 9%. The hip function scores improved post-surgery. In conclusion, the use of PFR in non-neoplastic conditions remains a marginal tool, associated with low direct mortality and high complication rates, but we expect its use to increase in the near future.
The increase in the number of total hip arthroplasties (THAs) performed, also in younger and more active patients, has led to an increase in the number of revision surgeries [1,2,3,4,5]. Factors associated with revision THA, such as periprosthetic fractures, osteolysis, infections, and multiple surgical operations, contribute to bone stock loss of the proximal femur, which creates a challenge in femoral component positioning [6,7,8].
Treatment options mainly include the use of long revision stems, allograft-prosthesis composites (APC), and proximal femur replacement (PFR). However, when these options are not suitable solutions because of poor bone or tissue conditions, even more invasive procedures such as total femur replacement (TFR) and resection arthroplasty (RA) have been proposed [9,10,11,12,13,14,15].
PFR, developed initially as a tool for the management of neoplastic diseases, has slowly gained a role in the treatment of non-neoplastic conditions as a salvage procedure in patients with severe bone loss at the proximal femur (Fig. 1) [16,17,18].
PFR has some peculiar pros and cons. Two advantages are the possibility of early weight bearing since no bone healing is required and the avoidance of some of the complications associated with allograft use, such as risk of infective disease transmission and fractures. The surgical technique is relatively easy to perform, but it is associated with complications, including damage to the abductor hip muscles and an increased rate of infections when compared with primary THAs [9, 19,20,21].
Publications that specifically target the use of PFR for non-neoplastic conditions are scarce, with the last systematic review on the topic published in 2014 by Korim et al. . Given the rapid development of new materials and implants and the increased use of PFR in the non-oncologic setting, an up-to-date systematic review of the literature was performed to obtain a comprehensive picture on current surgical indications, complications, and functional results of these implants.
Materials and methods
The medical PubMed and MEDLINE databases and Cochrane Database of Systematic Reviews were analyzed on 17 November 2020, searching for relevant publications on the use of PFRs for non-neoplastic conditions. The databases were filtered for studies published between January 1980 and November 2020, in English language. The keywords used for the search were “Proximal femoral replacement” and “Hip megaprothesis.” References of relevant papers were then analyzed to find additional works pertinent to the topic.
Articles describing the use of proximal femoral replacement for the management of non-neoplastic conditions, published in English, were included. Conversely, articles were excluded if describing the use of proximal femoral replacement for the management of neoplastic pathology, if published in a language other than English, if regarding patients operated on for TFR, or if describing outcomes of fewer than five patients . Two studies [24, 27], despite being very informative, were excluded because a distinction between proximal and distal femoral replacements could not be made.
The titles and abstracts of the identified papers were analyzed and screened independently by two authors. The articles judged of interest were then selected for a full text analysis according to our inclusion and exclusion criteria. The Preferred Reporting Item for Systematic Reviews and Meta-Analyses (PRISMA) guidelines  were followed, and a flowchart was created to summarize the inclusion process of the analyzed works.
The level of evidence and the quality of each study was assessed by the methodological index for non-randomized studies (MINORS)  by two authors independently. It explores 12 elements, the first 8 developed to specifically evaluate quality of research in nonrandomized studies. These include clear statement of the study aim, inclusion of consecutive patients, prospective data collection, and appropriateness of the endpoint to the aim of the study, which should be unbiased; moreover, the follow-up of the study should be clearly reported as being appropriate for the aim of the study, with loss of less than 5% of patients at follow-up. Finally, a prospective calculation of the study size should be clearly stated in the material and methods section of the study. Each element is given a score from 0 to 2: 0 if not reported, 1 if reported but inadequate, 2 if reported and adequate. The ideal overall score for noncomparative studies is 16.
Data extraction and report
The selected studies were analyzed, and the information of interest was extracted onto a database created using Microsoft Excel for Microsoft Mac (Microsoft Corporation, Redmond, Washington, USA).
The following data were recorded, if available: number of patients, age of patients, number of previous surgeries, length of follow-up, performed surgical approach, type of implant used at index surgery, type of fixation including the use of bone cement, use of a constrained liner, indications to surgery, intra- and perioperative mortality (within 30 days from surgery), reoperation rate, revision rate (intended as the exchange of any of the prosthesis’ components), postoperative complications (loosening, dislocation, periprosthetic fracture, infection, hematoma, wound healing problems), and hip functional scores. The extracted data were reported with the use of descriptive statistics. Continuous variables were reported as average and range (minimum–maximum). Categorical variables were reported as frequencies and percentages.
The primary outcomes were the surgical indications for the use of PFRs and the surgical approach used for these implants.
The secondary outcomes were the failure rate and 30-day mortality. Failure was defined as the need for reoperation, due to mechanical (subclassified as loosening, dislocation, fracture of prosthesis component, or periprosthetic fracture) or nonmechanical reasons (subclassified as infection, hematoma, or wound dehiscence needing incision and drainage), according to the classifications used in the last systematic review on the topic . Surgeries requiring partial or total implant replacement were recorded and reported as revisions.
The tertiary outcome was the comparison of the hip functioning scores in the pre- and postoperative period.
The primary and secondary outcomes were further divided according to the date of publication (before versus after 1 January 2010), and the extracted data were compared with the use of chi-squared test to identify statistically relevant differences. Chi-squared tests of independence were performed to determine whether the proportions of one nominal variable were different for different values of the other nominal variable.
The null hypothesis was that the relative proportions of one variable were independent of the second variable. If chi-squared test was significant, the data were further investigated using pairwise comparisons with Bonferroni corrections of the P values. Statistical significance was set at P < 0.05.
The study selection process is summarized in Fig. 2, using the PRISMA flowchart. The initial search yielded 3806 papers. On the basis of title and abstract, 3705 studies were excluded because they were considered not relevant to the present study. The remaining 85 papers were evaluated in detail to verify the congruence with the inclusion criteria. After full text screening, a total of 27 studies met the inclusion criteria.
Study quality assessment
All the selected studies were retrospective case series of small to medium size (N = 5–80) reporting the outcomes of the use of PFR for non-neoplastic conditions. Manuscripts were published between 1980 and 2020. According to the MINORS evaluating score system, 2 studies reported 6/16 points [30, 31], and another 2 reported 7/16 points [11, 32]; 15 studies achieved 8/16 points [16, 19, 20, 22, 23, 33,34,35,36,37,38,39,40,41,42], 1 achieved 10/16 points , and 7 had a score of 12/16 [17, 18, 21, 43,44,45,46].
The studies included 828 patients (Table 1) with a mean age of 70.9 years (minimum 22 years to maximum 102 years); average follow-up was 50 months (1–225 months). Patients had an average of 2.6 surgeries before PFR, with four patients having the implant at first surgery, and one patient after 22.
Indications and surgical technique
The most frequent indication for PFR in non-neoplastic conditions (Table 2) was infection (28%, 234/828 patients), followed closely by periprosthetic fracture (27%, 225/828 patients) and aseptic loosening (22%, 186/828 patients). Primary fractures accounted for 16% of cases (135/828 patients) and other conditions for 6% (48/828).
The most frequently used implants were MRS and GMRS (32%, 261/828), followed by Stanmore (13%, 107/828), MUTARS (11%, 94/828), and METS (11%, 90/828). The implant was fixed with the use of acrylic cement in 90.4% of patients. A constrained liner was used in 10.3% (85/828) of patients.
Surgery was performed by the direct lateral approach in 32% of patients (268/828), followed by the posterolateral (18%, 148/828), posterior (16%, 132/828), and anterolateral (8%, 69/828) approaches. Surgical approach was not reported in 25% of patients (211/828).
Indications to surgery evolved overtime, with aseptic loosening more common in manuscripts published before 2010 (34% versus 18%; p < 0.0001); conversely, infection has been a more frequent indication in studies since 2010 (36% versus 9%; p < 0.0001). No significant differences were found for surgical indications in trauma patients operated on for fractures (p = 0.109) and periprosthetic fractures (p = 0.4).
The most frequently reported postoperative complication was dislocation (10.2%, 82/801), followed by infection (7.4%, 59/801) and aseptic loosening (5.0%, 40/801). The fracture of prosthetic components was a rare event occurring in only two patients (0.2%).
Of the 82 dislocations, 38 (46%) underwent a closed reduction, whereas 54% underwent an open reduction during which liner and/or head was exchanged to either a constrained liner or a bigger-sized head.
Of the 59 infections, antibiotic-only treatment was used in five cases (8%). In 24 patients (41%), a debridement of the infected prosthesis was performed, retaining the original components. Twenty-four patients (41%) underwent a two-stage revision in which the prosthetic components were first explanted and then re-implanted after resolution of the infective process. Four patients (7%) underwent resection arthroplasty, and in one patient a conversion to total femur replacement was performed (2%). One patient died because of infection.
Of the 39 patients in whom an aseptic loosening occurred, 29 (74%) were revised for failure of the acetabular or femoral component, and 3 were revised by an APC implant. In four patients (10%) an RA was performed, and three patients (8%) were operated on for conversion to TFR.
Of the 19 periprosthetic fractures, only 4 were treated conservatively. The rest underwent osteosynthesis (21%), revision of the prosthetic components (53%), or conversion to TFR (5%).
Overall, the PFR was revised in 163 (15.4%) patients. The 30-day mortality ranged from 0% to 9%, with an average of 1.4% (11/801).
Reoperations were more frequent in cohorts reported before 2010 compared with reports since 2010 (25.5% versus 18.2%; p = 0.021); main causes of revision surgery were mechanical loosening (9.4% versus 3.2%; p = 0.0003) and dislocations (15.7% versus 7.9%; p = 0.0009). No significant differences were found regarding 30-day mortality (p = 0.523), rate of revision (p = 0.236), periprosthetic fracture (p = 0.770), infection (p = 0.697), or wound healing problems (p = 0.909).
Hip function scores
Function scores were reported in 21/27 studies [10, 11, 16, 17, 19,20,21,22, 31,32,33,34,35,36,37,38, 40, 42, 44,45,46] (Table 4), generally showing an improvement from preoperative to postoperative. The most frequently used score was the Harris Hip Score (HHS) , followed by the Oxford Hip Score . In the studies where the HHS was used, there was an average improvement of 33 points between preoperative (average 40) and postoperative (average 73) scores.
The use of PFR for non-neoplastic conditions remains a marginal surgical tool. In the current systematic review, the main indications for surgery are infection (28%), periprosthetic fracture (27%), and aseptic loosening (22%). The most frequent complications are dislocation (10.2%) and infection (7.3%) with an overall reoperation rate of 20.3%. The 30-day mortality ranges between 0% and 9%. Interestingly, a reduced rate of complications in studies published after 2010 was found. In particular, there were significantly fewer reoperations for any reason (18.2% versus 25.5%), fewer loosenings (3.2% versus 9.4%), and fewer dislocations (7.9% versus 15.7%). Conversely, no differences in infection rates before or after 2010 were observed (6.8% versus 7.6%) despite the significant prevalence in infection as an indication to PFR after 2010 (36% versus 9% of patients). A nonsignificant trend toward fewer implant revisions has been observed in studies since 2010 (14.3% versus 17.9%).
The main limitations of the present study are connected to the low level of evidence and quality of the included manuscripts. In many studies, the sample size is extremely small and the follow-up is not long enough to correctly include the whole clinical history of the patients. A systematic review of the subject, by pooling the data together, can overcome the limitation of small sample size. Moreover, the time range of published manuscripts spans over almost 40 years, during which the surgical techniques and technologies have evolved, possibly creating distortions in the obtained results. For this reason, a further analysis on primary and secondary outcomes of literature before and after 2010 was performed.
The common characteristic of all the patients involved in the included studies was the extensive poor quality of the proximal femoral bone stock, mostly described as type IIIA and IIIB according to the classification of Della Valle and Paprosky . Because of such deficiency in case of primary fracture, periprosthetic fracture, component loosening, or infection, the available treatment options are quite scarce, and mainly include PFR and APC. Only in some favorable cases is the use of revision stems alone advisable in this setting, and the outcomes connected to their use are associated with an overall reduction in complication rates compared with data of PFR reported in the current review (Table 5).
Weiss et al. , in their study reporting the outcome of 1885 revisions managed by a long revision stem, found an 11% reoperation rate. The main complications were aseptic loosening in 25 (1.3%), dislocations in 19 (1.0%), deep infection in 9 (0.5%), periprosthetic fracture in 9 (0.5%). In a similar study on 9952 revisions cases, re-revisions accounted for 13.2% ; reported complications included aseptic loosening (3.1%), dislocation (3.0%), and infection (2.9%). Regarding functional outcomes, Saleh et al.  reported the results of 2163 revisions and found an improvement of 37 points from preoperative to postoperative HHS. The reported re-revision rate was 5.9%, dislocations occurred in 7.8%, deep infection in 4.9%, acetabular loosening in 5.8%, and femoral fatigue fracture in 3.1% . However, the use of revision stems is only rarely an option in patients with severe bone loss. When cemented implants are used, the length of the stem, cemented in place, should extend distally by at least two femoral diameters beyond the area of cancellous bone defect to minimize the risk of loosening , often not possible because of the entity of bone loss.
Another alternative is the use of allograft, either fresh-frozen or freeze-dried  with a long-stemmed revision prosthesis cemented in the allograft, and press fitted in the host femur, the APC. The procedure carries its own complications (Table 5), mainly including fracture or non-union, but has the peculiar advantage of direct tendon sutures at the enthesis on the graft . However, failure is reported in up to 11–20% of patients  requiring revision surgery to PFR in most cases, rarely to TFR, or performance of an RA .
A review of 498 hips managed with this technique outlines a non-union rate of 25.2% (range 0–77%), a dislocation rate of 12.8% (range 0–55%), and the need for a revision surgery in 16.8% (range 5–34%) . Some authors report even a higher revision rate when the technique is used. Babis et al.  evaluated the use of APC in 72 patients with severe bone loss. Subsequent revision was performed in 26.5%, with an overall reoperation rate of 59.7%. These complication rates make the APCs more appropriate for younger patients, in which the chance of graft integration is higher, and in which tendon reconstruction is aimed at a more functional hip [69,70,71], keeping in mind that PFR is a viable option in most cases of APC failure.
Salvage procedures in these patients may require TFR and resection arthroplasty [64, 67]. TFR is usually performed when there is less than 120–130 mm of intact diaphyseal or distal femoral bone available, making it unsuitable for other reconstruction techniques . It allows a functional improvement of 14–35 HHS points postoperatively , but recent reports outlined a failure rate of 21–30% for these implants, with common complications including deep infection in 4–35%, dislocation in 6–28%, structural failure in 9%, and aseptic loosening in 4% [63, 64].
RA is mainly performed in non-ambulating patients or in those in whom a reimplantation is considered too risky or prone to failure when the residual femoral length is such to avoid major shortening of the inferior limb . This technique as a salvage procedure allows pain relief in 85–100%, but it is associated with a wide range of satisfaction rates, from low values like 13% to values as high as 83% . In a recent study of 38 hips managed by RA, the procedure was associated with a 10% death rate, a 15% joint infection rate, an 8% reoperation rate, and a 21% rate of major systemic complication . Both TFR and RA are associated with elevated complication rates, mostly connected to the general health status of the patient, and the invasiveness of the surgery, and should be performed in selected patients for whom alternative methods of reconstruction are not suitable.
In conclusion, the use of PFR in the setting of non-neoplastic conditions remains a limited but useful tool that is expected to increase in the near future. It is a valid option in patients with severe proximal femur bone loss after trauma, and in THA failures due to infections, trauma, or mechanical failure. In recent years, outcomes of PFR have been improving, and in experienced hands, mortality directly related to the surgery is low. However, both the surgeons and the patients should be aware of the rates of complications and reoperations associated with this technique.
In the future, multicenter prospective studies on the indications and long-term results of PFR for non-neoplastic conditions could give a broader and better understanding of their benefits and drawbacks, providing data of the utmost importance to improve patient outcome.
Availability of data and materials
Every article analyzed to extract the data is present and available on the search engines used.
NJR Editorial Board (2018). National Joint Registry for England, Wales, Northern Ireland and Isle of Man. 15th Annual report 2018. http://www.njrcentre.org.uk/njrcentre/Reports-Publications-and-Minutes/Annual-reports. Accessed 09 Apr 20
No authors listed (2018). Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR). Hip, Knee & Shoulder Arthroplasty. 2018 Annual Report. Adelaide. AOA 2018. https://aoanjrr.sahmri.com/annual-reports-2018. Accessed 9 April 20
Karrholm J, Mohaddes M, Odin D, Vinblad J, Rogmark C, Rolfson O (2017) Swedish Hip Arthroplasty Register Annual Report 2017. https://registercentrum.blob.core.windows.net/shpr/r/Eng_Arsrapport_2017_Hoftprotes_final-Syx2fJPhMN.pdf. Accessed 9 Apr 2020
Kurtz S, Ong K, Lau E et al (2007) Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 89:780–785. https://doi.org/10.2106/JBJS.F.00222
Cavagnaro L, Formica M, Basso M et al (2017) Femoral revision with primary cementless stems: a systematic review of the literature. Musculoskelet Surg. https://doi.org/10.1007/s12306-017-0487-7
Holt G, Hook S, Hubble M (2011) Revision total hip arthroplasty: the femoral side using cemented implants. Int Orthop 35:267–273. https://doi.org/10.1007/s00264-010-1167-5
Amanatullah DF, Howard JL, Siman H et al (2015) Revision total hip arthroplasty in patients with extensive proximal femoral bone loss using a fluted tapered modular femoral component. Bone Jt J 97-B:312–317. https://doi.org/10.1302/0301-620X.97B3.34684
Aprato A, Tosto F, Comba A et al (2021) The clinical and economic burden of proximal femur periprosthetic fractures. Musculoskelet Surg. https://doi.org/10.1007/s12306-020-00694-4
Parvizi J, Sim FH (2004) Proximal femoral replacements with megaprostheses. Clin Orthop 420:169–175. https://doi.org/10.1097/00003086-200403000-00023
Al-Taki MM, Masri BA, Duncan CP, Garbuz DS (2011) Quality of life following proximal femoral replacement using a modular system in revision THA. Clin Orthop Relat Res 469:470–475. https://doi.org/10.1007/s11999-010-1522-2
Grammatopoulos G, Alvand A, Martin H et al (2016) Five-year outcome of proximal femoral endoprosthetic arthroplasty for non-tumour indications. Bone Jt J 98-B:1463–1470. https://doi.org/10.1302/0301-620X.98B11.BJJ-2016-0244.R1
Rasouli MR, Porat MD, Hozack WJ, Parvizi J (2012) Proximal femoral replacement and allograft prosthesis composite in the treatment of periprosthetic fractures with significant proximal bone loss: Vancouver B3 periprosthetic fracture. Orthop Surg 4:203–210. https://doi.org/10.1111/os.12000
Rogers BA, Sternheim A, De Iorio M et al (2012) Proximal femoral allograft in revision hip surgery with severe femoral bone loss. J Arthroplasty 27:829-836.e1. https://doi.org/10.1016/j.arth.2011.10.014
Ahmed AR (2010) Total femur replacement. Arch Orthop Trauma Surg 130:171–176. https://doi.org/10.1007/s00402-009-0945-2
Piccioli A, Rossi B, Sacchetti FM et al (2015) Fractures in bone tumour prosthesis. Int Orthop 39:1981–1987. https://doi.org/10.1007/s00264-015-2956-7
Malkani AL, Settecerri JJ, Sim FH (1995) Long-term results of proximal femoral replacement for non-neoplastic disorders. J Bone Jt Surg Br 77:351–356
Parvizi J, Tarity TD, Slenker N et al (2007) Proximal femoral replacement in patients with non-neoplastic conditions. J Bone Jt Surg 89:1036–1043. https://doi.org/10.2106/JBJS.F.00241
Fenelon C, Murphy EP, Kearns SR et al (2020) Cemented proximal femoral replacement for the management of non-neoplastic conditions: a versatile implant but not without its risks. J Arthroplasty 35:520–527. https://doi.org/10.1016/j.arth.2019.09.010
Viste A, Perry KI, Taunton MJ et al (2017) Proximal femoral replacement in contemporary revision total hip arthroplasty for severe femoral bone loss: a review of outcomes. Bone Jt J 99-B:325–329. https://doi.org/10.1302/0301-620X.99B3.BJJ-2016-0822.R1
McLean AL, Patton JT, Moran M (2012) Femoral replacement for salvage of periprosthetic fracture around a total hip replacement. Injury 43:1166–1169. https://doi.org/10.1016/j.injury.2012.03.024
Alvand A, Grammatopoulos G, de Vos F et al (2018) Clinical outcome of massive endoprostheses used for managing periprosthetic joint infections of the hip and knee. J Arthroplasty 33:829–834. https://doi.org/10.1016/j.arth.2017.09.046
Klein GR (2005) Proximal femoral replacement for the treatment of periprosthetic fractures. J Bone Jt Surg Am 87:1777. https://doi.org/10.2106/JBJS.D.02420
Lundh F, Sayed-Noor AS, Brosjö O, Bauer H (2014) Megaprosthetic reconstruction for periprosthetic or highly comminuted fractures of the hip and knee. Eur J Orthop Surg Traumatol 24:553–557. https://doi.org/10.1007/s00590-013-1237-7
De Gori M, Scoccianti G, Frenos F et al (2016) Modular endoprostheses for nonneoplastic conditions: midterm complications and survival. BioMed Res Int 2016:1–5. https://doi.org/10.1155/2016/2606521
Di Martino A, Martinelli N, Loppini M et al (2017) Is endoprosthesis safer than internal fixation for metastatic disease of the proximal femur? A systematic review. Injury 48:S48–S54. https://doi.org/10.1016/S0020-1383(17)30658-7
Korim MT, Esler CNA, Ashford RU (2014) Systematic review of proximal femoral arthroplasty for non-neoplastic conditions. J Arthroplasty 29:2117–2121. https://doi.org/10.1016/j.arth.2014.06.012
Smith EL, Shah A, Son SJ et al (2020) Survivorship of megaprostheses in revision hip and knee arthroplasty for septic and aseptic indications: a retrospective, multicenter study with minimum 2-year follow-up. Arthroplasty Today 6:475–479. https://doi.org/10.1016/j.artd.2020.05.004
Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535–b2535. https://doi.org/10.1136/bmj.b2535
Slim K, Nini E, Forestier D et al (2003) Methodological index for non-randomized studies (MINORS): development and validation of a new instrument: Methodological index for non-randomized studies. ANZ J Surg 73:712–716. https://doi.org/10.1046/j.1445-2197.2003.02748.x
Bosquet M, Burssens A, Mulier JC (1980) Long term follow-up results of a femoral megaprosthesis: a review of thirteen patients. Arch Orthop Trauma Surg 97:299–304. https://doi.org/10.1007/BF00380712
Haentjens P, De Boeck H, Opdecam P (1996) Proximal femoral replacement prosthesis for salvage of failed hip arthroplasty: complications in a 2–11 year follow-up study in 19 elderly patients. Acta Orthop Scand 67:37–42. https://doi.org/10.3109/17453679608995606
Sim FH, Chao EY (1981) Hip salvage by proximal femoral replacement. J Bone Jt Surg 63:1228–1239. https://doi.org/10.2106/00004623-198163080-00004
Shih S-T, Wang J-W, Hsu C-C (2007) Proximal femoral megaprosthesis for failed total hip arthroplasty. Chang Gung Med J 30:8
Jaiswal PK, Jagiello J, David LA et al (2008) Use of an ‘internal proximal femoral replacement’ with distal fixation in revision arthroplasty of the hip. J Bone Joint Surg Br 90:11–15. https://doi.org/10.1302/0301-620X.90B1.19494
Schoenfeld AJ, Leeson MC, Vrabec GA et al (2008) Outcomes of modular proximal femoral replacement in the treatment of complex proximal femoral fractures: a case series. Int J Surg 6:140–146. https://doi.org/10.1016/j.ijsu.2008.01.009
Bertani A, Helix M, Louis ML et al (2009) Total hip arthroplasty in severe segmental femoral bone loss situations: use of a reconstruction modular stem design (JVC IX™). Orthop Traumatol Surg Res 95:491–497. https://doi.org/10.1016/j.otsr.2009.07.011
Gebert C, Wessling M, Götze C et al (2010) The modular universal tumour and revision system (MUTARS®) in endoprosthetic revision surgery. Int Orthop 34:1261–1265. https://doi.org/10.1007/s00264-010-1007-7
Dean BJF, Matthews JJ, Price A et al (2012) Modular endoprosthetic replacement for failed internal fixation of the proximal femur following trauma. Int Orthop 36:731–734. https://doi.org/10.1007/s00264-011-1332-5
Calori GM, Colombo M, Malagoli E et al (2014) Megaprosthesis in post-traumatic and periprosthetic large bone defects: issues to consider. Injury 45:S105–S110. https://doi.org/10.1016/j.injury.2014.10.032
Patel NK, Whittingham-Jones P, Aston WJ et al (2014) Custom-made cement-linked mega prostheses: a salvage solution for complex periprosthetic femoral fractures. J Arthroplasty 29:204–209. https://doi.org/10.1016/j.arth.2013.03.032
De Martino I, D’Apolito R, Nocon AA et al (2019) Proximal femoral replacement in non-oncologic patients undergoing revision total hip arthroplasty. Int Orthop 43:2227–2233. https://doi.org/10.1007/s00264-018-4220-4
Fahad S, Nawaz Khan MZ, Khattak MJ et al (2019) Primary proximal femur replacement for unstable osteoporotic intertrochanteric and subtrochanteric fractures in the elderly: a retrospective case series. Ann Med Surg 44:94–97. https://doi.org/10.1016/j.amsu.2019.07.014
Colman M, Choi L, Chen A et al (2014) Proximal femoral replacement in the management of acute periprosthetic fractures of the hip: a competing risks survival analysis. J Arthroplasty 29:422–427. https://doi.org/10.1016/j.arth.2013.06.009
Corona PS, Vicente M, Lalanza M et al (2018) Use of modular megaprosthesis in managing chronic end-stage periprosthetic hip and knee infections: Is there an increase in relapse rate? Eur J Orthop Surg Traumatol 28:627–636. https://doi.org/10.1007/s00590-018-2127-9
Khajuria A, Ward J, Cooper G et al (2018) Is endoprosthetic replacement of the proximal femur appropriate in the comorbid patient? HIP Int 28:68–73. https://doi.org/10.5301/hipint.5000520
Dieckmann R, Schmidt-Braekling T, Gosheger G et al (2019) Two stage revision with a proximal femur replacement. BMC Musculoskelet Disord. https://doi.org/10.1186/s12891-019-2442-2
Harris WH (1969) Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. J Bone Joint Surg Am 51:737–755
Wylde V, Learmonth ID, Cavendish VJ (2005) The Oxford hip score: the patient’s perspective. Health Qual Life Outcomes 3:66. https://doi.org/10.1186/1477-7525-3-66
Enneking WF, Dunham W, Gebhardt MC et al (1993) A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system. Clin Orthop 286:241–246
Clayer M, Doyle S, Sangha N, Grimer R (2012) The Toronto extremity salvage score in unoperated controls: an age, gender, and country comparison. Sarcoma 2012:1–5. https://doi.org/10.1155/2012/717213
Saleh KJ, Mulhall KJ, Bershadsky B et al (2005) Development and validation of a lower-extremity activity scale: use for patients treated with revision total knee arthroplasty. J Bone Jt Surg 87:1985–1994. https://doi.org/10.2106/JBJS.D.02564
Della Valle CJ, Paprosky WG (2003) Classification and an algorithmic approach to the reconstruction of femoral deficiency in revision total hip arthroplasty. J Bone Jt Surg-Am 85:1–6. https://doi.org/10.2106/00004623-200300004-00001
Saleh KJ, Celebrezze M, Kassim R et al (2003) Functional outcome after revision hip arthroplasty: a metaanalysis. Clin Orthop 416:254–264. https://doi.org/10.1097/01.blo.0000093006.90435.43
Weiss RJ, Stark A, Kärrholm J (2011) A modular cementless stem vs. cemented long-stem prostheses in revision surgery of the hip: a population-based study from the Swedish Hip Arthroplasty Register. Acta Orthop 82:136–142. https://doi.org/10.3109/17453674.2011.566145
Kenney C, Dick S, Lea J et al (2019) A systematic review of the causes of failure of revision total hip arthroplasty. J Orthop 16:393–395. https://doi.org/10.1016/j.jor.2019.04.011
Landa J, Benke M, Dayan A et al (2009) Fracture of fully coated echelon femoral stems in revision total hip arthroplasty. J Arthroplasty 24:322.e13-322.e18. https://doi.org/10.1016/j.arth.2007.12.010
Busch CA, Charles MN, Haydon CM et al (2005) Fractures of distally-fixed femoral stems after revision arthroplasty. J Bone Joint Surg Br 87-B:1333–1336. https://doi.org/10.1302/0301-620X.87B10.16528
Vastel L, Lemoine CT, Kerboull M, Courpied JP (2007) Structural allograft and cemented long-stem prosthesis for complex revision hip arthroplasty: use of a trochanteric claw plate improves final hip function. Int Orthop 31:851–857. https://doi.org/10.1007/s00264-006-0275-8
Babis GC, Sakellariou VI, O’Connor MI et al (2010) Proximal femoral allograft-prosthesis composites in revision hip replacement: a 12-year follow-up study. J Bone Joint Surg Br 92:349–355. https://doi.org/10.1302/0301-620X.92B3.23112
Safir O, Kellett CF, Flint M et al (2009) Revision of the deficient proximal femur with a proximal femoral allograft. Clin Orthop 467:206–212. https://doi.org/10.1007/s11999-008-0573-0
Lee SH, Ahn YJ, Chung SJ et al (2009) The use of allograft prosthesis composite for extensive proximal femoral bone deficiencies. J Arthroplasty 24:1241–1248. https://doi.org/10.1016/j.arth.2009.06.006
Lombardi AV, Berend KR (2006) The shattered femur: radical solution options. J Arthroplasty 21:107–111. https://doi.org/10.1016/j.arth.2006.01.007
Medellin MR, Fujiwara T, Clark R et al (2019) Mechanisms of failure and survival of total femoral endoprosthetic replacements. Bone Jt J 101-B:522–528. https://doi.org/10.1302/0301-620X.101B5.BJJ-2018-1106.R1
DeRogatis MJ, Issack PS (2018) Total femoral replacement as a salvage operation for the treatment of massive femoral bone loss during revision total hip arthroplasty. JBJS Rev 6:e9. https://doi.org/10.2106/JBJS.RVW.17.00195
Ramanathan D (2015) Current concepts in total femoral replacement. World J Orthop 6:919. https://doi.org/10.5312/wjo.v6.i11.919
Malcolm TL, Gad BV, Elsharkawy KA, Higuera CA (2015) Complication, survival, and reoperation rates following Girdlestone resection arthroplasty. J Arthroplasty 30:1183–1186. https://doi.org/10.1016/j.arth.2015.02.011
Cordero-Ampuero J (2012) Girdlestone procedure: when and why. HIP Int 22:36–39. https://doi.org/10.5301/HIP.2012.9568
Philippe H, Nicolas D, Jerome D et al (2015) Long, titanium, cemented stems decreased late periprosthetic fractures and revisions in patients with severe bone loss and previous revision. Int Orthop 39:639–644. https://doi.org/10.1007/s00264-014-2528-2
Tsiridis E, Spence G, Gamie Z et al (2007) Grafting for periprosthetic femoral fractures: strut, impaction or femoral replacement. Injury 38:688–697. https://doi.org/10.1016/j.injury.2007.02.046
Wilke BK, Houdek MT, Rose PS, Sim FH (2019) Proximal femoral allograft-prosthetic composites: do they really restore bone? A retrospective review of revision allograft-prosthetic composites. J Arthroplasty 34:346–351. https://doi.org/10.1016/j.arth.2018.10.020
Kellett CF, Boscainos PJ, Maury AC et al (2007) Proximal femoral allograft treatment of Vancouver type-B3 periprosthetic femoral fractures after total hip arthroplasty. Surgical technique. J Bone Joint Surg Am 89(Suppl 2 pt.1):68–79. https://doi.org/10.2106/JBJS.F.01047
Vincenten CM, Gosens T, van Susante JC, Somford MP (2019) The Girdlestone situation: a historical essay. J Bone Jt Infect 4:203–208. https://doi.org/10.7150/jbji.36618
The authors gratefully acknowledge Prof. Roberta Aronica for English revision of the current manuscript.
The authors received no financial support for the research, authorship and/or publication of this article.
Ethical approval and consent to participate
No ethical approval was necessary for this study.
Consent for publication
No consent to publish was necessary for this study.
The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Di Martino, A., Pederiva, D., Bordini, B. et al. Proximal femoral replacement for non-neoplastic conditions: a systematic review on current outcomes. J Orthop Traumatol 23, 18 (2022). https://doi.org/10.1186/s10195-022-00632-z
- Proximal femoral replacement
- Hip arthroplasty
- Revision surgery