Functional and quality of life outcome after non-operatively managed proximal humeral fractures
© The Author(s) 2017
Received: 11 February 2017
Accepted: 11 July 2017
Published: 22 August 2017
Fractures of the proximal humerus are common and most often treated non-operatively. However, long-term follow-up studies focusing on functional results and quality of life in patients after this type of fracture are scarce. The primary aim of this study is to report the long-term functional and quality of life outcome in patients with a proximal humeral fracture.
Materials and methods
A retrospective analysis of all consecutive patients undergoing non-operative treatment for a proximal humeral fracture in a level 2 trauma centre between January 2000 and December 2013 was performed. A database consisting of all relevant demographic, patient and fracture characteristics was created. Subsequently, a questionnaire containing the DASH (Disabilities of the Arm, Shoulder and Hand) score, EuroQol-5D (EQ-5D), VAS (visual analogue scale) score, and subjective questions was sent to all patients.
A total of 410 patients (65 male, 345 female) were included for analyses. Average follow-up was 90 ± 48 months. DASH-scores <15 were considered as good. A median DASH-score of 6.67 [0.83–22.50] was found. A significant lower DASH-score was seen in patients under the age of 65 compared to older patients (p < 0.001). In comparison to an age-matched general Dutch population, Health related Quality of Life (HrQoL) on the EQ-us was not significantly worse in our study population (difference 0.02). Strong (negative) correlation was found between DASH-score and VAS-score, and DASH-score and HrQoL, respectively ρ = −0.534 and ρ = −0.787.
Long-term functional and quality of life outcomes are good in most patients after proximal humeral fractures, but negatively correlated to each other.
Level of evidence
Proximal humeral fractures are frequently seen on emergency departments and encompass around 5% of all fractures. In the US an annual incidence of 60 per 100,000 persons per year has been reported . These fractures are unipolar distributed by age, therefore, incidences up to 260 per 100,000 persons per year are described in woman between 80 and 89 years of age . Mostly, they tend to occur in mobile elderly woman as a consequence of decreased bone density mass. Only fractures of the (distal) radius and the hip are more frequently seen, making it the third most common fracture in this particular group [4, 22, 23, 32]. A 50% increase in incidence of this fracture is expected due to the ageing of the population [16, 26, 34].
Of all fractures of the proximal humerus, about 85–90% are considered suitable for non-operative treatment: Immobilization for one or two weeks, followed by phsysiotherapy . In these cases, fractures usually only show minor displacement, as well as little angulations, healing uneventfully in the future . Indications for surgical treatment are usually based on factors like age, number of fragments, degree of displacement, baseline functional status of the patient, hand dominance, and surgical experience of the treating physician . Nevertheless, no consensus has been reached yet, whether to perform conservative or surgical treatment after a proximal humeral fracture in particular cases.
Since the bones affected by a proximal humeral fractures are part of a joint, they can be classified as articular fractures, and sometimes even intra-articular. Therefore, the question arises if arthroses will occur. Therefore, long-term follow-up is needed. Formerly, until today fracture consolidation was the most important goal in therapy. Nowadays, functional outcome and quality of life (QoL) are increasingly important .
Most previous published studies report short-term results up to 24 months after non-operative treatment or compare different treatment modalities [8, 10, 30, 31, 35, 38]. Long-term results focusing on patient reported outcomes are lacking. Therefore, purpose of this large cohort study was to report long-term functional and quality of life outcomes after conservative treatment of fractures of the proximal humerus.
Materials and methods
All successive patients, who underwent non-operative treatment after a proximal humeral fracture between the first of January 2000 and the 31st of December 2013 at our trauma-surgical department were cross-sectionally analyzed. Our hospital is categorized as a Level 2 trauma centre in this region, where over 40,000 patient are treated annually at the accident and emergency department. Our study was approved by our local medical ethics committee and is also in line with the policy statement, declared in the Declaration of Helsinki (1975), as revised in 1983.
All patients presenting with a fracture of the proximal humerus at the emergency department in the aforementioned timeframe, were included. Exclusion criteria were (1) an age under 18 years old at presentation, (2) patients who had surgical intervention after non-operative treatment was started, (3) patients who suffered from severe cognitive impairment and, therefore, were unable to fill out the questionnaires, (4) patients who were deceased at the time of this study, (5) unavailable contact information, and (6) patients who did not provide informed consent for participation.
Data extraction methods
Relevant patient characteristics as well as demographic data and medical histories were gathered from the patient medical records, together with characteristics of the fracture and follow-up data.
Outcome measures were retrieved by the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and the Euro-Qol 5Dimensions (EQ-5D) questionnaire. An additional questionnaire to retrieve information on dominance, occupation, and pre-injury functioning was also added. This questionnaire has not been validated. The three questionnaires were sent by regular post. If response failed to appear, patients were reminded by telephone contact once.
Disabilities of the arm, shoulder and hand (DASH)
The DASH questionnaire is a questionnaire that has been designed to be completely filled out by patient without assistance of a physician. It measures the disability of the upper extremity, as well as any symptoms occurring in the preceding week, concerning the health status of a patient. Also, an optional module is added about functionally hazards during work and sports [9, 14]. It has been validated for the proximal part of the upper arm  and is also available in Dutch . There are no standardized cut-off points or benchmarks to categorize the DASH score, but cut-off points often used in recent literature are defined as good (no or minimal problems) if <15 points, moderate (problems, still working) if 15–40 points, and poor (problems, not working) if >40 points were obtained [1, 17].
Health-related quality of life (HrQoL)
The HrQoL was obtained by letting patients fill out the Euro-Qol 5Dimensions (EQ-5D) questionnaire [18, 37]. It is translated and validated into the Dutch language, and also tested on its repeatability, taking age- and sex-adjusted population norms into account . This QoL-questionnaire has, just like the DASH questionnaire, been designed to be filled out completely by patient without any assistance and it includes five questions and an visual analogic self-perception (VAS) scale, ranging from 0 to 100) . Also, the EQ-5D has been proven to show a good internal and external responsiveness for patients suffering from a fracture of the proximal humerus .
The EuroQol-utility score (EQ-us) was calculated with the EQ self-classifier. In this article we used the UK EQ-5D index tariff, in absence of a Dutch index tariff, for all health states possible [5–7, 33].
With this calculated index tariff, a single index value can be linked for all possible states of health, where some are hypothetical. Maximum index score is set at 1.00, representing a state of full health. The score indicated by patients on the visual analogic self-perception scale can also be compared and referred with the index tariff.
The reference population we used consisted of a sample of Dutch population, comparable to our cohort (n = 4504, UK-tariff): age 50–97 years old (mean = 64, SD = 10), 45% males and 77% low standing diseases like low back pain, asthma and diabetes .
Categorical variables are reported in percentages and frequency, where continuous variables are presented in mean plus/minus standard deviation (±SD) or median and interquartile ranges 25th–75th percentile dependent on distribution. The Mean-Whitney U test was used for testing for significance at differences in outcomes between dichotomous characteristics. For nominal patient variables we used the Kruskal–Wallis test. Considered as statistically significant, were p values of less than 0.05. Spearman’s rank correlation test was applied to compute associations between the DASH scores and HrQoL.
For conducting all statistical analyses SPSS statistical software 22.0, Chicago, for Microsoft Windows was used.
A total of 410 patients (out of 738) completely filled out and returned the questionnaires, leading to a response rate of 56%. Two-hundred and eighty patients did not respond and 48 patients had to be excluded for returning incomplete (and, therefore, non-usable) questionnaires.
Of all patients included for analyses, 65 were male (16%) and 345 female (84%) with a mean age of 62 ± 12.1 years at the time of fracture and an average follow-up time of 90 ± 48 months. 136 (36%) were 2-part, 158 (40%) 3-part and 97 (25%) were 4-part fractures. 19 X-ray photos were not available anymore at the department of Radiology because of expired medical record retention, so percentages are calculated where 100% is equal to n = 391.
Baseline characteristics of the cohort, surviving the follow-up (n = 410 patients,) returning the questionnaire completely filled out the DASH and QoL questionnaires
n = 410
70 ± 12.0
Age at fracturea
62 ± 12.1
Fracture at dominant limbb
Parts of fractureb,c
Months since fracture
89.7 ± 47.9
Functional outcome of the shoulder
DASH-score within patient characteristics
Parts of fracture
When dividing our cohort in a relatively younger cohort (≤65 years old at the time of fracture, n = 248) and an old cohort (n = 162), we found significantly different median DASH-scores of 5.0 [0.0–15.0] versus 12.50 [3.13–31.67, p < 0.001], respectively.
Multiple regression analysis on our data, showed significant correlations in age (at the time of fracture, ρ = 0.293, p < 0.001) and the number of fracture parts (ρ = 0.143, p = 0.005). No significant correlation was seen between number of months since fracture (ρ = −0.014, p = 0.401).
The optional work-module was filled out completely by 161 patients (39%). Of those, 126 patients reported no problems at all (78%), 25 (16%) reported mild problems, 7 (4%) moderate problems, one patient (<1%) reported severe problems, and only two patients (<1%) were not able to carry out work-related activities anymore due to the fracture. For this (working) subgroup, a median DASH-score of 5.0 [0.0–14.17] was found.
The optional module considering doing sports or playing an instrument was fully completed by 150 (37%) patients. A median DASH-score of 3.75 [0.0–13.75] was found in this subgroup.
At the time of this survey, 169 (41%) patients reported a similar function of the upper extremity compared to the function before fracture [median DASH-score 0.0 (0.0–5.0)]. In 187 (45%) patients, function of the upper arm was slightly reduced with no major disabilities after fracture [median DASH-score 10.83 (5.0–21.88)], and 54 (13%) patients reported major or severe decrease in functionality [median DASH-score 44.58 (30.0–56.04)].
No complaints of pain were documented in 268 (65%) patients and 39 (10%) patients endured pain at least once a month. Only 20 (5%) patients endured pain less than once a day, but less than once a week, and pain was present daily or continuously in 63 (15%) patients. A significant (p < 0.001) difference was seen in median DASH score between the group with no pain [2.50 (0.0–8.96)] compared to the group still enduring pain [24.58 (11.67–42.71)].
Health related quality of life
n = 410
n = 248
n = 162
0.82 ± 0.26
0.85 ± 0.23
0.78 ± 0.28
Impairment in dimensionc
Usual activity (%)
76.2 ± 16.0
77.9 ± 15.1
73.5 ± 16.4
A strong negative correlation was found between DASH-score and the self-reported VAS score, ρ = −0.534, p = 0.01. An even stronger correlation, p = 0.01, was seen between the DASH-score and EQ-US-score, ρ = −0.777.
A significant difference was found in the mean EQ-US-score, comparing the younger patients (age ≤65 at the time of the fracture) versus the old patients subgroup (age >65), with a negative effect for the latter group, p = 0.021.
Quality of life outcome comparison between the Dutch reference population and our study cohort, and subdivided by patients younger or equal to 65 and older than 65 years of age at the time of fracture
Refer. Pop 
n = 4504
n = 410
0.84 ± 0.22
0.82 ± 0.26
Impairment in dimensionc
Usual activity (%)
Aim of this study was to report the functional outcomes and Health related Quality of Life of patients with a proximal (subcapital) fracture of the humerus treated non-operatively. Since current literature lacks long-term follow-up studies, our study yields some important findings which could definitely be used to inform people about the potential functional disabilities they can expect after treatment. Most importantly we found a good median DASH-score (of 6.67) in our cohort, with a long average follow-up time of 90 ± 48 months.
Proximal, and more specifically, subcapital humeral fractures are in the minds of both patients and physicians often associated with an expected decrease in function of the shoulder . Our long-term follow-up study does not necessarily support this assumption. The low median DASH-score in our study indicates that most of patients perceived functional outcomes after a fracture of the proximal humerus are excellent (DASH-score <15 points). Comparison with current literature is difficult because of the absence of similar long follow-up periods. Comparison with pre-fracture scores is obviously not possible, whilst people do not plan the proximal humeral fracture. Other discrepancies between studies might derive from differences in patient characteristics such as gender, age, amount of parts, or the presence of co-morbidities .
Comparison can be made with studies examining patients reported shoulder functioning after surgically managed proximal humeral fractures. The comparison especially is interesting in the discussion whether to treat non-operatively or surgically. Current literature mainly consist of short-term studies up to 24 months, reporting post-operative DASH-scores, varying between 16 and 35 points [3, 12, 15, 20, 28, 29, 36]. As mentioned, our study is about long-term functional outcomes and these data are unfortunately also scarce after surgical treatment. However, recently a few long-term follow-up studies have been published, reporting DASH-scores after surgery ranging from 12 to 30 points [2, 11, 27, 30], which are comparable to our results after non-operative treatment. Our study is the first actually reporting these outcomes in a long-term timeline. Also our high response rate of 56%, despite a high average age and the long follow-up period, makes our study valid and of suitable quality.
The reason we preferred DASH questionnaire, to measure functional outcome, over other instruments like the Oxford Shoulder (OSS) and the UCLA shoulder score is that DASH has a very broad scope in functioning of the whole upper extremity. Therewith, limitation of the DASH is that many items may seem irrelevant to patients, especially to patient with a specific condition. Secondly a disadvantage of a specific instruments as the DASH questionnaire is that it does not take into account the history of patients filling out the questionnaire, which can point out lower DASH scores not related to the fracture .
Some limitations can be allocated to our study. Obviously, our Study is of a retrospective nature, making it hard to include all consecutive patients since the start of the study, providing some bias in our results. Also, only a post-treatment outcome of the DASH and EQ-5D questionnaire is reported, preventing us to compare the functional and HrQoL outcome with outcomes before the fracture. Rather interesting is the change in (perceived) health, instead of the health at the end of the follow-up period. This would have eliminated bias of other co-morbidities and ageing. Nevertheless, we have added the comparison to an age- and gender matched population to overcome this limitation. Therefore, our outcomes give a good image of what disabilities can be expected after non-operative treatment.
Another limitation lies in the fact that the QoL was only measured at one certain point in time (2015). Because of this, follow-up time of the HrQoL differs from 2 to 16 years, making it hard to interpret these results. If scores were obtained with the same amount of time between fracture and measurement, results were less difficult to clarify.
Thirdly, our overall response rate is 56%. This response is a result of our long follow-up period and a relatively old population (with associated comorbidities like dementia). It is also doubtful whether patients with minimal functional loss will take time to fill out the complete questionnaire.
Although some limitations can be pointed out, useful information on the functional outcomes of proximal humeral fractures after non-operative treatment has been provided.
In conclusion, the long-term functional outcomes, after a non-operatively treated proximal humeral fractures, appears to be good in almost two-third of the patients (66%). Only 10% still suffers from serious impairments or experiences considerable disabilities in daily functioning. Patients with a worse DASH-score also scored lower on the HrQoL score. These outcomes are valuable to inform patients with a proximal humeral fracture about the outcome of non-operative treatment.
Compliance with ethical standards
Conflict of interest
No conflict of interest occurred.
All patients gave the informed consent prior to being included into the study.
Research involving human participants
All procedures involving human participants were in accordance with the 1964 Helsinki declaration and its later amendments.
The study was approved by the research ethics committee.
No source of funding was received for our study. All authors, their immediate family, and any research foundation with which we are affiliated did not receive any financial payments or other benefits from any commercial entity related to the subject of this article.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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