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Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 1 Summary of articles included in this systematic review

From: Preoperative antibiotic prophylaxis and the incidence of surgical site infections in elective clean soft tissue surgery of the hand and upper limb: a systematic review and meta-analysis

 

Main author and year

Country

Study design

Follow-up (days)

Surgical procedures

Demographic characteristics

Number of participants

1

Aydin N

(2010) [14]

Turkey

Single-center clinical, randomized, double-blind, placebo-controlled trial

180

Patients underwent surgeries for contracture, soft tissue laceration, carpal tunnel release and fasciotomy, fasciectomy for palmar fibromatosis, tumor excision, tendon injury, nerve injury and/or vessel injury, and tendon transfer

Mean age

30.92 ± 2.4 years

Sex (M/F)

74.4%/25.6%

This study excluded patients with immunosuppression and other comorbidities, such as diabetes and smoking

1340

Total number of participants who meet the eligibility criteria for this systematic review: 426

2

Bykowski MR

(2011) [16]

USA

Single-center retrospective observational study

79

Patients underwent surgeries for carpal tunnel release (n = 3783), trigger finger release (n = 1992), first extensor compartment release (n = 1046), wrist cyst excision (n = 625), excision of subfascial tumor in the hand (n = 421), release of the ulnar nerve at the wrist (n = 392), ulnar nerve transposition at the elbow (n = 358), excision of subcutaneous tumor of the hand (n = 201), excision of subcutaneous tumor of the forearm and wrist (n = 32)

Mean surgery time: 27 ± 21 min

 

8,850

3

Bäcker HC

(2021) [15]

USA

Multicenter, prospective nonrandomized clinical study

42

Patients underwent open carpal tunnel release (n = 143), revision of carpal tunnel release (n = 2), endoscopic carpal tunnel release (n = 54), trigger finger release (n = 134), first extensor compartment release (n = 26), fasciectomy for palmar fibromatosis (n = 16), cubital tunnel release (n = 1), tenosynovectomy of flexor tendons (n = 3), excision of tumors (n = 102), foreign body excision (n = 1), nail biopsy (n = 1), implant removal (n = 1)

Mean age

61 years

Sex (M/F)

38.5%/61.5%

434

4

Harness NG

(2010) [4]

USA

Multicenter, retrospective observational study

30

Surgeries performed: open and endoscopic carpal tunnel release and carpal tunnel release revision

 

2336

5

Hoel RJ

(2018) [17]

USA

Single-center, retrospective observational study

30

Surgeries performed were wrist arthroscopy; 116 patients (36%) underwent concomitant open procedures, 6 also involved the use of skin closure material and belonged to the group that received preoperative antibiotics; therefore, they were excluded from data analysis and from this systematic review

Diabetes mellitus

3%

Smoking

13%

324

Total number of participants who meet the eligibility criteria for this systematic review: 318

6

Johnson SP

(2018) [7]

USA

Multicenter, retrospective observational study assessing databases of medical claims

30

Surgeries analyzed: open carpal tunnel release (n = 209,275), endoscopic carpal tunnel release (n = 48,282), trigger finger release (n = 4490), first extensor compartment release (n = 20,598), removal of tumor at the wrist (n = 23,301)

Sex (M/F)

35%/65%

Diabetes mellitus

25.2%

Charlson comorbidity index

0–52.4%/1% to 3–8.3%

4% to 8–22%/ > 8%–17,3%

305,946

Total number of participants who meet the eligibility criteria for this systematic review: 285,642

7

Li K

(2018) [18]

USA

Multicenter, retrospective observational study assessing databases of medical claims

30

Patients underwent surgeries of carpal tunnel release (n = 250,613), trigger finger release (n = 119,390), first extensor compartment release (n = 25,972), removal of tumor at the wrist (n = 121,011)

Sex (M/F)

64%/36%

516,986

8

Mehta S

(2022) [19]

USA

Single-center, retrospective observational study

30

Patients underwent surgeries of carpal tunnel release

Mean age

59 ± 14 years

Sex (M/F)

35.2%/64.8%

IMC

34 ± 9.4 kg/m2

Diabetes mellitus

26.6%

Smoking

12.7%

HbA1c > 7

10%

ESRD

1.7%

770

9

Tosti R

(2012) [20]

USA

Multicenter, retrospective observational study

30

Patients underwent surgeries of carpal tunnel release (n = 300), trigger finger release (n = 175), first extensor compartment release (n = 44), removal of tumor at the wrist (n = 81)

Diabetes mellitus

23.8%

Smoking

20.8%

600

10

Vasconcelos C

(2017) [21]

Portugal

Single-center, retrospective observational study

30

Patients underwent surgeries of carpal tunnel release (n = 211), trigger finger release (n = 68), first extensor compartment release (n = 61), removal of tumor at the wrist (n = 6)

Mean surgery time: 19.6 min, with all eligible participants undergoing procedures with surgery time of less than 30 min

Mean age

58.4 years

Sex (M/F)

14.4%/85.6%

Comorbidities

70.8%

Diabetes mellitus

14.4%

346

11

Wachtel N

(2023) [22]

Germany

Multicenter, ambispective observational study

30

Patients underwent wrist soft tissue arthroscopy. Most arthroscopy procedures performed involved pathology of the triangular fibrocartilage complex (30.9%), the other procedures included arthroscopic resection of cysts (23.6%), purely diagnostic arthroscopy with or without synovectomy (18.5%), combined procedures (19.1%), procedures involving pathologies of the intrinsic ligaments of the wrist (5.1%), among others, such as loose body removal (2.8%)

Mean surgery time: 40.4 ± 18.1 min

Mean age

38.1 years

Sex (M/F)

42.7%/57.3%

Comorbidities

61.2%

Diabetes mellitus

1.7%

Smoking

24.7%

Alcohol consumption

18%

IT

5.6%

Prior SSI

2.2%

178; of these, 56.2% were recruited retrospectively and 43.8% were recruited prospectively

12

Zheng A

(2022) [23]

USA

Single-center, retrospective observational study

30

Patients underwent surgeries of cubital tunnel release

Mean age

54.6 (12–87) years

Sex (M/F)

52.7%/47.3%

919

  1. M male, F female, BMI body mass index, HbA1c glycosylated hemoglobin, SSI surgical site infection, ESRD end-stage renal disease, IT immunosuppressive therapy