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Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 5 Septic nonunion detection rates when using one positive TC in combination with another confirmatory diagnostic criterion

From: The value of sonication in the differential diagnosis of septic and aseptic femoral and tibial shaft nonunion in comparison to conventional tissue culture and histopathology: a prospective multicenter clinical study

Confirmatory criteria for the diagnosis of septic nonunion

No. of detected septic nonunions

Sensitivity % (95% CI)

 ≥ 2 Positive TCs with the same pathogen

23/42

55 (39–70)

 ≥ 1 Positive TC  + histopathology with infection signs

10/42

24 (13–40)

 ≥ 1 Positive TC + same pathogen in SF broth culture

23/42

55 (39–70)

 ≥ 1 Positive TC  + same pathogen in MF (≥ 0.6 CFU/10 ml)

26/42

62 (46–76)

 ≥ 1 Positive TC + same pathogen in MF (≥ 13.6 CFU/10 ml)

21/42

50 (34–66)

  1. TC tissue culture, CI confidence interval, SF sonication fluid, MF membrane-filtrated sonication fluid, CFU colony-forming units