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Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 4 Performances of different test methods when discriminating between aseptic and septic nonunion

From: The value of sonication in the differential diagnosis of septic and aseptic femoral and tibial shaft nonunion in comparison to conventional tissue culture and histopathology: a prospective multicenter clinical study

 

Septic nonunion

Aseptic nonunion

Sensitivity

Specificity

PPV

NPV

Regular healers

Test method

No. of patients who tested positive

% (95% CI)

No. of patients who tested positive

Long-term TC (study sample)

29/42

2/53

69 (53–82)

96 (86–99)

94 (77–99)

80 (67–88)

3/32

Histopathology (study sample)

6/42

7/53

14 (6–29)

87 (74–94)

46 (20–74)

56 (45–67)

5/32

SF broth culture

29/42

10/53

69 (53–82)

81 (68–90)

74 (58–86)

77 (63–87)

9/32

MF (≥ 0.6 CFU/10 ml)

33/42

20/53

79 (63–89)

62 (48–75)

62 (48–75)

79 (63–89)

10/32

MF (≥ 13.6 CFU/10 ml)

22/42

4/53

52 (37–68)

93 (81–98)

85 (64–95)

71 (59–81)

3/32

  1. PPV positive predictive value, NPV negative predictive value, CI confidence interval, TC tissue culture, SF sonication fluid, MF membrane-filtrated sonication fluid