Official Journal of the Italian Society of Orthopaedics and Traumatology
From: Risk factors for preoperative deep venous thrombosis in hip fracture patients: a meta-analysis
Factors | I2 (%) | P | OR | 95% CI | P | |
---|---|---|---|---|---|---|
 |  |  |  | Lower | Upper |  |
Age | 0 | 0.52 | 0.13 | 0.06 | 0.21 | 0.0003 |
 60–70 years vs > 90 years | 0 | 0.32 | 0.04 | 0.01 | 0.32 | 0.002 |
 70–80 years vs > 90 years | 0 | 0.84 | 0.25 | 0.10 | 0.60 | 0.002 |
 80–90 years vs > 90 years | 0 | 0.83 | 0.23 | 0.09 | 0.63 | 0.004 |
 60–70 years vs 70–80 years | 35 | 0.22 | 0.73 | 0.44 | 1.22 | 0.23 |
 60–70 years vs 80–90 years | 28 | 0.25 | 0.77 | 0.47 | 1.27 | 0.31 |
 70–80 years vs 80–90 years | 0 | 0.99 | 1.02 | 0.68 | 1.52 | 0.93 |
Sex | 22 | 0.16 | 0.82 | 0.72 | 0.92 | 0.0009 |
Body mass index | 0 | 0.92 | 0.07 | − 0.03 | 0.17 | 0.19 |
  < 18.5 kg/m2 vs > 28 kg/m2 | 0 | 0.84 | 0.46 | 0.24 | 0.90 | 0.02 |
 24.0–27.9 kg/m2 vs > 28 kg/m2 | 0 | 0.38 | 0.59 | 0.39 | 0.91 | 0.02 |
 < 25 kg/m2 vs > 25 kg/m2 | 0 | 0.37 | 1.14 | 0.55 | 2.33 | 0.23 |
  < 18.5 kg/m2 vs 18.5–23.9 kg/m2 | 0 | 0.58 | 1.00 | 0.62 | 1.61 | 1.00 |
  < 18.5 kg/m2 vs 24.0–27.9 | 0 | 0.81 | 0.81 | 0.50 | 1.32 | 0.40 |
 18.5–23.9 kg/m2 vs 24.0–27.9 kg/m2 | 0 | 0.75 | 0.79 | 0.62 | 1.01 | 0.06 |
 18.5–23.9 kg/m2 vs > 28 kg/m2 | 0 | 0.60 | 0.71 | 0.45 | 1.12 | 0.14 |
Type of hip fracture | Â | Â | Â | Â | Â | Â |
 Intertrochanteric fracture vs femur neck fracture | 0 | 0.89 | 1.43 | 1.20 | 1.72 |  < 0.0001 |
 Intertrochanteric fracture vs subtrochanteric fracture | 0 | 0.53 | 0.28 | 0.14 | 0.55 | 0.0003 |
 Femur neck fracture vs subtrochanteric fracture | 0 | 0.48 | 0.34 | 0.19 | 0.60 | 0.0002 |
 Time from injury to surgery | 0 | 0.76 | 2.06 | 1.40 | 2.72 |  < 0.00001 |
  ≥ 5 days vs < 5 days | 0 | 0.68 | 4.54 | 2.50 | 8.25 |  < 0.00001 |
 Time from injury to admission | 0 | 0.49 | 0.54 | 0.44 | 0.65 |  < 0.00001 |
 Location | 0 | 0.36 | 1.07 | 0.72 | 1.58 | 0.75 |
 Allergy | 0 | 0.95 | 0.97 | 0.67 | 1.40 | 0.86 |
 Smoking | 0 | 0.50 | 1.45 | 1.11 | 1.89 | 0.007 |
 Thrombosis history | 0 | 0.52 | 5.28 | 2.85 | 9.78 |  < 0.00001 |
 Anti-platelet drug | 12 | 0.32 | 0.51 | 0.30 | 0.85 | 0.01 |
 Injury side | 0 | 0.84 | 0.84 | 0.68 | 1.03 | 0.09 |
 Injury mechanism | 0 | 0.54 | 0.58 | 0.38 | 0.87 | 0.009 |
ASA class | Â | Â | Â | Â | Â | Â |
 ASA III and ASA IV | 7 | 0.34 | 0.51 | 0.17 | 1.53 | 0.23 |
 ASA I and ASA II | 0 | 0.84 | 0.39 | 0.21 | 0.70 | 0.002 |
 ASA I and ASA III | 0 | 0.65 | 0.31 | 0.17 | 0.58 | 0.0002 |
 ASA I and ASA IV | 0 | 0.50 | 0.13 | 0.13 | 0.03 | 0.49 |
 ASA III and ASA IV | 0 | 0.90 | 0.21 | 0.06 | 0.79 | 0.02 |
 Hypertension | 0 | 0.55 | 1.03 | 0.91 | 1.16 | 0.63 |
 Diabetes | 0 | 0.75 | 1.13 | 0.90 | 1.42 | 0.28 |
 Coronary heart disease | 0 | 0.55 | 1.25 | 1.07 | 1.47 | 0.006 |
 Cerebrovascular accident | 0 | 0.52 | 1.09 | 0.92 | 1.30 | 0.32 |
 Cancer | 0 | 0.75 | 0.84 | 0.60 | 1.18 | 0.33 |
 Dementia | 4 | 0.37 | 1.72 | 1.10 | 2.67 | 0.02 |
 Liver and kidney Disease | 0 | 0.41 | 1.91 | 1.12 | 3.25 | 0.02 |
 Liver disease | 0 | 0.53 | 0.91 | 0.53 | 1.57 | 0.75 |
 Kidney disease | 0 | 0.42 | 1.26 | 0.84 | 1.88 | 0.26 |
 Pulmonary disease | 0 | 0.57 | 1.55 | 1.07 | 2.33 | 0.02 |
 Arrhythmia | 0 | 0.61 | 1.14 | 0.79 | 1.63 | 0.48 |
 Stroke | 0 | 0.66 | 1.02 | 0.64 | 1.64 | 0.92 |
 Alzheimer’s disease | 0 | 0.44 | 1.52 | 0.78 | 2.97 | 0.22 |
 Hemoglobin | 6 | 0.38 | − 0.32 | − 0.43 | − 0.21 |  < 0.00001 |
 Platelet | 0 | 0.56 | 2.03 | − 7.46 | 11.52 | 0.68 |
 Activated partial thromboplastin time | 0 | 0.51 | − 0.37 | − 0.78 | 0.04 | 0.08 |
 Prothrombin time | 0 | 0.86 | 0.15 | 0.00 | 0.30 | 0.05 |
 Fibrinogen | 0 | 0.73 | 0.20 | 0.08 | 0.32 | 0.0009 |
 D-dimer | 0 | 0.88 | − 0.20 | − 0.97 | 0.58 | 0.62 |
 C-reactive protein | 0 | 0.56 | 5.95 | 1.04 | 10.85 | 0.01 |
 Albumin | 0 | 0.74 | 1.42 | 1.10 | 1.82 | 0.006 |