Official Journal of the Italian Society of Orthopaedics and Traumatology
From: Antibiotic cement coating in orthopedic surgery: a systematic review of reported clinical techniques
Bone cement/bone substitute (± premixed antibiotics) | Antibiotic additives | Refs. |
---|---|---|
PMMA (DePuy, Inc., Warsaw, IN, USA) | 2.4 g tobramycin and 2 g vancomycin per 40 g, vacuum mixing | [10] |
PMMA (Stryker Rutherford) | 2 g vancomycin per 40 g | [29] |
PMMA, Palacos (Zimmer, Warsaw, Indiana) | 3.6 g tobramycin and 1 g vancomycin mixed with each 40-g patch of Palacos | [19] |
Not specified | 2 g vancomycin and 2 g gentamicin mixed per 40 g bone cement | [39] |
PMMA cement (Simplex; Howmedica, Rutherford, NJ) | 4 g vancomycin added to each 40 g PMMA cement | [17] |
PMMA, Palacos (Heraeus Kulzer, Hanau, Germany) | 2 g gentamycin per batch of Palacos cement (total two batches used) | [11] |
PMMA, Simplex P bone cement | 2 g cefuroxime and 2 g vancomycin added per 40 g Simplex P bone cement | [12] |
PMMA, not further specified | 2 g vancomycin and 2 g teicoplanin with each 40 g bone cement | [40] |
PMMA, Palacos | 2 g vancomycin and 2 g gentamycin per 40 g cement | [41] |
PMMA (Smith and Nephew, TN, USA) (premixed with gentamicin) | 2 g vancomycin with one batch of premixed gentamicin-containing PMMA cement | [9] |
Bone cement (not further specified) (premixed with gentamicin) | 4 g vancomycin mixed with 40 g gentamicin cement | [16] |
PMMA (Biomet Cobalt Bone Cement, Warsaw, IN) | 3.6 g tobramycin and 1 g vancomycin mixed with 40 g bone cement | [20] |
Simplex bone cement (Stryker, Mahwah, NJ) | 1–4 g antibiotics mixed with 40 g Simplex for 30 s before injecting | [15] |
PMMA, Simplex (Antibiotic Simplex, Stryker USA) | 4 g vancomycin and 4 g tobramycin with 40 g bone cement | [48] |
PMMA (Palacos R+G, Zimmer, Warsaw, IN, USA) (premixed with 0.5 g gentamicin) | 2 g vancomycin and 2.4 g tobramycin were each mixed with 40 g PMMA containing 0.5 g gentamicin | [42] |
PMMA cement (not further specified) (premixed with gentamicin) | No additional additives further specified | [13] |
PMMA bone cement (Simplex, Stryker Orthopedics, Rutherford, NJ) | 2.4 g tobramycin and 2 g vancomycin with two packs of 40 g PMMA | [30] |
PMMA bone cement (Simplex, Stryker Orthopedics, Rutherford, NJ) | 2.4 g tobramycin and 2 g vancomycin with two packs of 40 g PMMA | [31] |
PMMA, not further specified | 4 g vancomycin (or gentamycin, tobramycin, or imipenem, depending on culture results) per 40 g PMMA cement | [21] |
PMMA bone cement (PALACOSR) | 4 g vancomycin or 1.6 g gentamicin per 40 g PMMA | [32] |
PMMA bone cement (Simplex, Stryker, Kalamazoo, MI) | 2 g vancomycin and 3.6 g tobramycin per 40 g PMMA | [22] |
PMMA bone cement (Cobalt, Biomet Orthopedics, Inc., Warsaw, IN) | 1 g vancomycin and 3.6 g tobramycin per 40 g PMMA | [44] |
Hi-Fatigue G Bone Cement (Zimmer) PMMA [premixed with 0.9 g gentamycin sulfate (0.55 g gentamycin base)] | Additional 2.5 g vancomycin and 1.5 g tobramycin per 40 g bone cement | [45] |
Simplex bone cement (Stryker, Mahwah, NJ) | 4 vials vancomycin and 4 vials tobramycin | [37] |
PMMA (Stryker, Kalamazoo, MI) | 1 g vancomycin per 40 g cement | [33] |
PMMA (not further specified) | 3 g vancomycin and 3.6 g tobramycin per 40 g cement | [38] |
PMMA (Copal G+C, Heraeus, Hanau, Germany) (premixed with 1 g gentamicin and 1 g clindamycin per 40 g) | 2 g colistin per 40 g cement | [28] |
PMMA (not further specified) | 0.5 g gentamycin and 5 g vancomycin per 40 g cement | [34] |
Bone cement not specified | 3 g vancomycin and 3.6 g tobramycin per 40 g cement | [35] |
PMMA Palacos-R (Zimmer, Warsaw, IN) | 3 g vancomycin per 40 g cement Additional 3.6 g tobramycin in presence of polymicrobial Gram-negative cultures | [23] |
PMMA (not further specified) | 2 g vancomycin and 2.4 g tobramycin per 40 g cement | [18] |
PMMA (Cemex RX/Tecres Co., Verona, Italy) (premixed with 1.2 g gentamicin) | No additional antibiotics | [46] |
PMMA Palacos cement (not further specified) | 3 g vancomycin per 40 g cement | [14] |
Bone cement (premixed with gentamicin) (not further specified) | 4 g vancomycin per 40 g cement or 2 g vancomycin and 2.4 g tobramycin per 40 g cement | [24] |
PMMA (DePuy, Inc., Warsaw, IN, USA) | 2 g vancomycin per 40 g cement | [36] |
Bone cement (not further specified) | Not specified | [25] |
PMMA (Simplex P, premixed with tobramycin, Stryker, Mahwah, NJ) | 1 g vancomycin mixed additionally | [27] |
Bone cement (not further specified) | 2 g vancomycin and 2 g gentamicin per 40 g cement or other additives as per culture results (either tobramycin, gentamicin, or amikacin; doses not further specified) | [47] |
Cerament G, Cerament V (premixed with either vancomycin or gentamicin) | 5 mL Cerament G (17.5 mg gentamicin sulfate/mL paste), 10 mL Cerament V (66 mg vancomycin/mL paste) | [8] |
Cerament V (premixed with vancomycin) | 10 mL Cerament V (66 mg vancomycin/mL paste) | [26] |