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Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 2. List of statements categorised by consensus group – Consensus of: agreement, disagreement, neither agree nor disagree or consensus not reached

From: Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study

 

Statement category

Consensus of agreement (median score =  4 or 5)

PRP should only be considered in patients presenting with characteristic tennis elbow pain (lateral elbow pain exacerbated by wrist extension)

Patient selection

PRP should only be considered in patients who are experiencing considerable intrusion into their activities of daily life

Patient selection

PRP treatment can be considered in patients over the age of 18, with no upper age limit

Patient selection

PRP treatment can be considered in patients with manual or sedentary occupations

Patient selection

PRP treatment can be considered in both high demand (e.g., sports people) and low demand (e.g., office worker) patients

Patient selection

PRP is contraindicated in patients with known thrombocytopenia (less than 150,000 platelets per microlitre of whole blood)

Contraindication

A single spin cycle of 20 min or less is recommended

PRP formulation

PRP activation, through the addition of additives prior to its administration, is not required

PRP formulation

Once processed, PRP should be administered within 30 min

Administration technique

Needle fenestration is recommended over a single injection technique

Administration technique

Following the first administration of PRP, the patient should be reassessed to discern the need for repeated administration

Administration strategy

Surgery is recommended for patients in whom PRP treatment is not effective

Administration strategy

Immobilisation of the elbow following injection is not necessary

Post procedural care

Light loads should be avoided for the first 48 h following injection

Post procedural care

Acetaminophen (paracetamol) and weak opioid-based analgesia can be offered as required following PRP administration

Post procedural care

Clinical assessment is recommended to assess the outcome of PRP administration

Outcome assessment

A validated patient-reported outcome measure (PROM) (e.g., PRTEE, DASH, OES) should be collected in addition to clinical assessment

Outcome assessment

Consensus of disagreement (median score = 1 or 2)

PRP is contraindicated in patients with a coagulopathy

Contraindications

PRP is contraindicated in patients taking anticoagulant medication

Contraindications

Consensus of ‘neither agree nor disagree’ (median score =  3)

The maximum recommended platelet concentration of injected PRP is 5 × baseline

PRP formulation

The maximum recommended volume of PRP is 3 ml

PRP formulation

The addition of an anticoagulant to the whole blood sample is recommended prior to PRP preparation

PRP formulation

A 19 g is the recommended MAXIMUM size used to administer PRP

Administration technique

Consensus not reached

PRP should only be considered following at least 3 months of conservative therapy

Patient selection

PRP is contraindicated in patients with large wrist extensor tendon tears

Contraindication

PRP is contraindicated in patients with a dependence on non-steroidal anti-inflammatory drugs (NSAIDs)

Contraindication

PRP is contraindicated in patients who have received a steroid injection for treatment of their lateral epicondylar tendinopathy, within 3 months of the intended PRP treatment date

Contraindication

The minimum recommended platelet concentration of injected PRP is 2 × baseline

PRP formulation

The minimum recommended volume of PRP is 1 ml

PRP formulation

Leukocyte deplete PRP is the recommended formulation

PRP formulation

Local anaesthetic should be administered to the skin and subcutaneous tissue

Administration technique

Local anaesthesia should not be administered to the tendon

Administration technique

Ultrasound guidance should be utilised in all PRP injections for lateral epicondylar tendinopathy

Administration technique

A maximum of 3 administrations is recommended for each episode of lateral epicondylar tendinopathy

Administration strategy

If symptoms recur following a successful course of treatment, PRP injection can be reattempted

Administration strategy

Heavy loads should be avoided for 6 weeks

Post procedural care

Non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided for 1 week prior to PRP administration

Post procedural care

Non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided for at least 2 weeks following injection

Post procedural care

A visual analogue pain score (VAS) should be collected in addition to clinical assessment

Outcome assessment

Resolution of tendinosis on US or MRI can be utilised to assess outcome

Outcome assessment