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Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 3 Performance of serum NLR, CRP, ESR, and combination in the diagnosis of PJI

From: Limited value of serum neutrophil-to-lymphocyte ratio in the diagnosis of chronic periprosthetic joint infection

 

NLR

CRP

ESR

NLR + CRP

NLR + ESR

CRP + ESR

NLR + CRP + ESR

AUC

0.66

0.84

0.79

0.84

0.79

0.83

0.83

95% CI

0.58–0.73

0.77–0.89

0.72–0.85

0.77–0.89

0.72–0.85

0.76–0.88

0.76–0.88

p-Value

0.001

 < 0.001

 < 0.001

 < 0.001

 < 0.001

 < 0.001

 < 0.001

Threshold

2.56

7.00

43.00

Sensitivity (%)

57.41

72.22

68.52

72.22

68.52

64.81

64.81

Specificity (%)

77.88

82.69

81.73

82.69

81.73

92.31

92.31

PPV (%)

57.4

68.4

66.1

68.4

66.1

81.4

81.4

NPV (%)

77.9

85.1

83.3

85.1

83.3

83.5

83.5

+LR

2.60

4.17

3.75

4.17

3.75

8.43

8.43

−LR

0.55

0.34

0.39

0.34

0.39

0.38

0.38

Accuracy (%)

70.88

79.11

77.22

79.11

77.22

82.91

82.91

DOR

4.75

12.42

9.74

12.42

9.74

22.11

22.11

  1. PJI periprosthetic joint infection, NLR neutrophil-to-lymphocyte ratio, CRP C-reactive protein, ESR erythrocyte sedimentation rate, AUC area under the curve, CI confidence interval, PPV positive predictive value, NPV negative predictive value,  +LR positive likelihood ratio, −LR negative likelihood ratio, DOR diagnostic odds ratio