Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review

Migliorini, Filippo; Eschweiler, Jörg; Spiezia, Filippo; van de Wall, Bryan J. M.; Knobe, Matthias; Tingart, Markus; Maffulli, Nicola

doi:10.1186/s10195-021-00588-6

Journal of Orthopaedics and Traumatology

Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 2 Generalities and patient baseline of the included studies

From: Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review

Author, year	Journal	Study design	Follow-up (months)	Approach	Patients	Female (%)	Mean age	Mean BMI	Mean size (cm²)
Akgun et al. 2015 [18]	Arch Orthop Trauma Surg	RCT	24	Control group	7	57	32.3	24.1	2.9
Akgun et al. 2015 [18]	Arch Orthop Trauma Surg	RCT	24	Mini-arthrotomy	7	57	32.7	24.3	3
Basad et al. 2010 [17]	Knee Surg Sports Traumatol Arthrosc	RCT	24	Mini-arthrotomy	40	38	33	25.3
Basad et al. 2010 [17]	Knee Surg Sports Traumatol Arthrosc	RCT	24	Control group	20	15	37.5	27.3
Basad et al. 2015 [26]	Knee Surg Sports Traumatol Arthrosc	Non-RCT	60	Mini-arthrotomy	25	37	32	24
Becher et al. 2017	J Orthop Surg Res	RCT	36	Arthroscopy	25	32	33	24.9	4.8
				Arthroscopy	25	16	34	25.6	4.9
				Arthroscopy	25	40	34	25.1	5.2
Ebert et al. 2012 [27]	Arthroscopy	Non-RCT	24	Arthroscopy	20	50	34	26.6	2.7
Ebert et al. 2016 [28]	Am J Sports Med	Non-RCT	60	Arthroscopy	31	51	35	26	2.52
Efe et al. 2012 [29]	Am J Sports Med	Non-RCT	24	Mini-arthrotomy	15	60	26
Ferruzzi et al. 2008 [30]	J Bone Joint Surg	Non-RCT	60	Control group	48	38	32		6.4
Ferruzzi et al. 2008 [30]	J Bone Joint Surg	Non-RCT	60	Arthroscopy	50	28	31		5.9
Filardo et al. 2011 [31]	Am J Sports Med	Non-RCT	84	Arthroscopy	62	23	28		2.5
Filardo et al. 2014 [32]	Am J Sports Med	Non-RCT	84	Arthroscopy	131	35	29	24	2.3
Kon el al. 2011 [33]	Am J Sports Med	Non-RCT	61	Arthroscopy	22	32	46	24.7	2.6
Kon el al. 2011 [33]	Am J Sports Med	Non-RCT	58	Mini-arthrotomy	39	35	45	25.6	3.1
Marlovits et al. 2012 [34]	Am J Sports Med	Non-RCT	60	Mini-arthrotomy	24	12	35		5.1
Niemeyer et al. 2016 [35]	Am J Sports Med	RCT	12	Mini-arthrotomy	25	33	33	24.9	4.8
				Mini-arthrotomy	25	16	34	25.6	4.9
				Mini-arthrotomy	25	40	34	25.1	5.2
Niemeyer et al. 2019 [36]	Orthop J Sports Med	RCT	24	Mini-arthrotomy	52	36	36	25.7	2.2
Niemeyer et al. 2019 [36]	Orthop J Sports Med	RCT	24	Control group	50	44	37	25.8	2
Saris et al. 2014 [37]	Am J Sports Med	RCT	24	Mini-arthrotomy	72	37	35	26.2	4.8
Saris et al. 2014 [37]	Am J Sports Med	RCT	24	Control group	72		33	26.4
Siebold et al. 2018 [38]	Knee Surg Sports Traumatol Arthrosc	Non-RCT	34.8	Arthroscopy	30	36	36	23.8	6

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