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Official Journal of the Italian Society of Orthopaedics and Traumatology

Fig. 5 | Journal of Orthopaedics and Traumatology

Fig. 5

From: A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

Fig. 5

Emerging phenotypes and endotypes of osteoarthritis. ARGS: N-terminal neoepitope of the aggrecanase-mediated aggrecan degradation fragment; C1M: MMP-derived collagen degradation neoepitopes of collagen I; C3M: MMP-derived collagen degradation neoepitopes of collagen III; CRPM: MMP-depended degradation product of C-reactive protein; CTX-I: C-terminal telopeptide of collagen I; IL-6: interleukin-6; IL-17: interleukin-17; MCP-1: monocyte chemoattractant protein 1; MMP-3: matrix metalloproteinase-3; PIIBNP (N-terminal propeptide of procollagens IIB); sICAM-1: soluble intracellular adhesion molecule 1; sVCAM-1: soluble vascular cell adhesion molecule 1; TNF-α: tumor necrosis factor-alpha; TIMP-1: tissue inhibitor of metallopeptidase inhibitor 1; VEGF: vascular endothelial growth factor

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