Fig. 3

The odds ratio (OR) for progression in groups of patients with very low (Q1 from Fig. 2), low (Q2), and moderate (Q3) compared with high (Q4) levels of baseline PRO-C2. Progression was defined as any progression (JSN > 0) over 2-years in analyses including all subjects in NYU cohort and the placebo arm of SMC subcohort (n = 185, black) and individuals with baseline KL ≥ 2 (n = 156, grey). Analyses were adjusted for age, BMI, gender, VAS pain, and baseline medial JSW using logistic regression. Data are presented as OR and 95% confidence intervals (CI). Asterisks: **p < 0.01; *p < 0.05