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Official Journal of the Italian Society of Orthopaedics and Traumatology

Fig. 2 | Journal of Orthopaedics and Traumatology

Fig. 2

From: A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

Fig. 2

Association between baseline levels of PRO-C2 and 2-year radiographic progression (JSN). Patients were dichotomized based on the median to low and high levels of PRO-C2 and the degree of progression was compared in a the NYU and b the SMC cohort. c Assessment of “dose–response” of JSN as a function of PRO-C2 levels in the combined dataset (all subjects in NYU cohort and the placebo arm of SMC subcohort). Analyses were adjusted for age, BMI, gender, VAS pain, and baseline medial JSW using two-way analysis of covariates (ANCOVA). Data are presented as mean with standard error of mean (SEM). Asterisks: **p < 0.01; #p < 0.1

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