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Journal of Orthopaedics and Traumatology

Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 5 Approved drugs for postmenopausal osteoporosis. Reproduced (with permission) from Table 6 of the Guidance for the diagnosis, prevention and therapy of osteoporosis in Italy (Cianferotti and Brandi [73])

From: Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology

Drug

BMD

Vertebral fx

Nonvertebral fx

Hip fx

Alendronate

1

1

1

1

Clodronate 800 mg/day/os

1

1

1

 

Etidronate

1

1

  

Ibandronate

1

1

1c

 

Risedronate

1

1

1

1

Zoledronate

1

1

1

1

Teriparatide

1

1

1

 

PTH1-84

1

1

  

Strontium ranelate

1b

1

1

1c

ERTa

1

1

1

1

Raloxifene

1

1

  

Bazedoxifene

1

1

  

Denosumab

1

1

1

1

  1. Each number in a table cell is the level of evidence for the effect of the drug on BMD or fracture risk (fx) at a particular site
  2. aNo longer recommended because of side effects
  3. bAlso determined by strontium high-molecular weight per se
  4. cAs demonstrated by post hoc analyses
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