Official Journal of the Italian Society of Orthopaedics and Traumatology
Table 4 ROC curve characteristics: circulating proinflammatory mediators as potential biomarkers of PTOA progression
Parameter | AUC (95% CI) | p | Cutoff | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|---|
Plasma (PTOA vs control) | |||||
NO x | 0.888 (0.826–0.949) | < 0.00001 | > 18.73 μM/L | 84.4 | 100 |
Uric acid | 0.774 (0.653–0.894) | < 0.00001 | > 280.45 μM/L | 70 | 77.8 |
IL-6 | 0.753 (0.655–0.851) | < 0.00001 | > 2.06 pg/mL | 65.5 | 84.2 |
IL-1β | 0.730 (0.587–0.872) | 0.007 | > 1.15 pg/mL | 68.2 | 69.2 |
Leptin | 0.694 (0.535–0.852) | 0.028 | > 3.59 ng/mL | 65.7 | 75 |