Tourniquet use during total knee arthroplasty does not modulate the neutrophil-to-lymphocyte ratio, pain, or activity

Table 2 Perioperative blood chemistries and outpatient physical therapy data

	T−	T+	Tourniquet main effect p value	Time main effect p value	Interaction p value	Time-pairwise comparison p-values
	T−	T+	Tourniquet main effect p value	Time main effect p value	Interaction p value	Pre vs 1 day	Pre vs 2 days	1-day vs 2 days
Hemoglobin, g/dL			0.47	<0.001	0.10	<0.001	<0.001	<0.001
Pre	14.0 (1.5)	14.0 (1.6)
1-day post	12.0 (1.5)	12.2 (1.4)
2-day post	11.0 (1.3)	11.3 (1.3)
Hematocrit, %			0.77	<0.001	0.78	<0.001	<0.001	<0.001
Pre	40.9 (5.6)	40.9 (6.5)
1-day post	35.6 (4.3)	35.7 (4.1)
2-day Post	32.7 (3.7)	33.1 (3.8)
WBC, K/uL			0.15	<0.001	0.50	<0.001	<0.001	<0.001
Pre	7.34 (2.42)	6.60 (1.50)
1-day post	11.2 (3.0)	10.3 (2.8)
2-day post	9.63 (2.33)	9.22 (2.00)
Neutrophils, K/uL			0.38	<0.001	0.47	<0.001	<0.001	<0.001
Pre	4.37 (1.34)	4.04 (1.24)
1-day post	8.75 (2.31)	8.21 (2.64)
2-day post	6.78 (1.59)	6.72 (1.65)
Lymphocytes, K/uL			0.58	<0.001	0.27	<0.001	0.004	0.001
Pre	2.06 (1.26)	1.88 (0.57)
1-day post Post	1.38 (1.42)	1.17 (0.54)
2-day post Post	1.64 (1.23)	1.72 (1.08)
NLR			0.44	<0.001	0.80	<0.001	<0.001	<0.001
Pre	2.40 (0.89)	2.35 (1.06)
1-day post	8.62 (5.00)	8.19 (4.07)
2-day post	5.41 (3.32)	4.82 (2.35)
∆1	6.23 (4.96)	5.78 (3.88)	0.61
∆2	2.99 (3.16)	2.44 (2.04)	0.29
∆1-2	−3.23 (5.40)	−3.34 (3.79)	0.91
Pain			0.20	<0.001	0.46
First PT visit	5.22 (2.24)	4.79 (2.23)
Last PT visit	3.28 (2.67)	2.42 (1.82)
Pain ∆	−2.42 (2.09)	−1.94 (3.10)	0.36
Pain responder	26	33	0.24
KOS			0.82	<0.001	0.87
First PT visit	46.7 (17.1)	47.9 (16.9)
Last PT visit	68.6 (18.4)	69.9 (17.0)
KOS ∆	21.9 (16.3)	21.8 (19.3)	0.98
KOS responder	36	42	0.31

Data presented as mean (SD)
T− non-tourniquet-assisted TKA, T+ tourniquet-assisted TKA, PT physical therapy, WBC white blood cell, ∆1 change from Pre to 1 day, ∆2 change from Pre to 2 days, ∆1-2 change from 1 day to 2 day