Official Journal of the Italian Society of Orthopaedics and Traumatology
Table 1 Review of cases of shoulder myeloid sarcoma with clinical details, treatment given, and outcome
Study no. | Age | Sex | Author | Year | Clinical presentation | Time of presentation with shoulder sarcoma | Additional findings | Imaging features | Systemic involvement | Underlying diagnosis | Molecular/cytogenetic abnormalities | Treatment given | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | 35 | M | Levy et al. [2] | 2014 | Right posterior shoulder pain | Initial presentation at diagnosis | Firm mass at the back, axillary lymphadenopathy | Lytic lesion in inferior angle of scapula | 2 % blasts in periphery (CML-CP) | CML | BCR-ABL1 (p210) rearrangement | Dasatinib followed by allogeneic SCT | Not reported |
2. | 38 | M | Upadhyay et al. [3] | 2014 | Right shoulder pain | Diagnosed case of CML since 2009, on hydroxyurea for last 2 years | Swelling over anterolateral aspect of right proximal arm, splenomegaly | Soft tissue mass lesion involving proximal part of right humerus with cortical breaks in the humeral head and neck completely encasing and infiltrating it | CML-CP | CML | Not available | Systemic chemotherapy and RT | Died 6 months after diagnosis |
3. | 39 | M | Cozzi et al. [4] | 2004 | Incidentally found to have myeloid sarcoma following a fracture after accident | Diagnosed as CML in 1989, received interferon, hydroxyurea and imatinib | Pain in left shoulder | Proximal humerus osteolytic lesion associated with extensive substitutive tissue | Bone marrow in CP | CML | Not available | Imatinib +dexamethasone + cytarabine followed by local RT | Died due to mycotic pulmonary infection |
4. | 40 | M | Alkubaidan et al. [5] | 2007 | Painful swelling of left shoulder 1 year after Allo-SCT | Diagnosed as SDS in teenage years, on pancreatic enzyme supplementation, with history of MDS, and underwent Allo-SCT 1 year back | Avulsion fracture of greater tubercle | Soft tissue mass circumferentially engulfing the proximal humerus, the rotator cuff and the long head of biceps tendon | NA | Shwachman-Diamond syndrome (SDS) | NA | NA | NA |
5. | 13 | M | Lincopan et al. [6] | 2011 | Mass in right shoulder | Initial presentation | Mass in inner thigh, rib cage, middle-posterior mediastinum | Soft issue masses in the sub-dermal region | Not present | Isolated MS | Trisomy 11 | NA | NA |
6 | 35 | F | Jain et al. [1] | 2016 | Pain and swelling of left shoulder | Diagnosed as CML-CP in 2004 (on Imatinib 400 mg OD), progressed to AP in 2014 (imatinib 600 mg) and had left shoulder pain in 2015 | Redness and induration of left shoulder, splenomegaly | MRI of the left shoulder showing an ill-defined heterogeneously enhancing lesion involving the muscles around the shoulder and infiltrating into clavicle | CML-CP (peripheral blood and Bone marrow) | CML | BCR-ABL (H396R mutation in kinase domain) | High dose imatinib, hydroxyurea, low dose cytarabine and local radiotherapy (RT) | NA |