Official Journal of the Italian Society of Orthopaedics and Traumatology
Table 1 Prognostic factors for BC metastatic to bone
From: Breast cancer bone metastases: an orthopedic emergency
Dimension, histotype, grading of primary tumor |
Disease-free interval |
First metastasis organs |
Estrogen and progesterone receptor status, Her2 |
Resistance to systemic therapies |
Solitary or multiple skeletal lesions |
Type of lesions (mixed, lytic, sclerotic) |
Skeletal localization |
Asymptomatic or symptomatic bone disease (SREs) |
Risk of pathological fracture (impending or complete) |
Radiation sensitivity |
Concomitant non-skeletal metastases |
ECOG performance status (Karnofsky score) |
Estimated life expectancy above or below 6Â months |