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Official Journal of the Italian Society of Orthopaedics and Traumatology

Fig. 4 | Journal of Orthopaedics and Traumatology

Fig. 4

From: Structural and biomechanical responses of osseous healing: a novel murine nonunion model

Fig. 4

Critical defect (1.6 mm) at 2 weeks postsurgery shows inadequate healing of the defect. a X-ray of bone, plate, and screws shows no healing. b DIC image also reveals no mineralization. Note the capping of the bone ends on the proximal side. c Fluorescence imaging shows capped proximal end, with strong periosteal response on the posterior surface. Positive TRAP staining is seen in growth plate chondrocytes along with some TRAP+ osteocytes. d AP staining (red) shows active bone around screw holes and along capped end. e Hematoxylin staining shows fibrous tissue in defect space with some muscle. Note poor-quality marrow between proximal screws

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