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Official Journal of the Italian Society of Orthopaedics and Traumatology

Fig. 3 | Journal of Orthopaedics and Traumatology

Fig. 3

From: Structural and biomechanical responses of osseous healing: a novel murine nonunion model

Fig. 3

Subcritical defect (0.6 mm) at 5 weeks postsurgery shows adequate healing of the defect. a X-ray image of the bone with the plate and the screws intact. b DIC image shows that the anterior side (near the plate) is bridged and the posterior side (away from the plate) is spanned by both direct extension and fusion of bone-like trabeculae. c Fluorescence imaging reveals that osteoclasts (TRAP+ cells) are attacking original bone beneath the extension/bridging. Bridged section shows some GFP activity. d AP staining (red) is present in the marrow cavity and especially between the two distal screws (on the left). e Hematoxylin staining reveals the variable quality of the marrow space

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