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Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 3 Low-molecular-weight heparin (LMWH) products available in Italy

From: II Italian intersociety consensus statement on antithrombotic prophylaxis in orthopaedics and traumatology

Active

principle

Brand name

Dose and timing

Enoxaparin

Clexane®

4,000 IU 12 h before the operation, then 4,000 IU/day

Nadroparin

Fraxiparina®

Seleparina®

38 IU/kg 12 h before the operation and 12 h afterward, 38 IU/kg every 24 h over the next 3 days after surgery, then increasing the dose to 57 IU/kg/day

Dalteparin

Fragmin®

5,000 IU 8–12 h before the operation, then 5,000 IU/day

Alternatively, 2,500 IU 1–2 h before surgerya and 2,500 IU 8–12 after, then 5000 IU/day

Bemiparin

Ivor®

3,500 IU 6 h after surgery, then 3,500 IU/day

Alternatively, 3,500 IU 2 h before surgerya, then 3,500 IU/day

Parnaparin

Fluxum®

4,250 IU anti-Xa 12 h before the operation, then 4,250 IU anti-Xa/day

Reviparin

Clivarina®

4,200 IU anti-Xa 12 h before the operation, then 4,200 IU anti-Xa/day

  1. aDespite the manufacturer’s instructions, pre-operative administration is not advised for these specific patients by this working group