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Official Journal of the Italian Society of Orthopaedics and Traumatology

Fig. 5 | Journal of Orthopaedics and Traumatology

Fig. 5

From: Ewing’s sarcoma as second malignancy following a short latency in unilateral retinoblastoma

Fig. 5

a Low-power view showing tumor cells infiltrating into soft tissue in a cord-like pattern (stain, hematoxylin and eosin; original magnification, × 20). b High-power view showing malignant blue round tumor cells with scanty cytoplasm and dispersed chromatin along with many mitotic figures showing PAS positivity and conspicuously absent rosette formation, indicating a poorly differentiated high-grade tumor (stain, hematoxylin and eosin; original magnification, × 40). c Immunohistochemistry showing tumor cells with Mic-2 positivity but which are negative for neuron-specific enolase (stain, immunohistochemical; original magnification, × 20)

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