Italian intersociety consensus statement on antithrombotic prophylaxis in hip and knee replacement and in femoral neck fracture surgery

Journal of Orthopaedics and Traumatology

Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 5 Correlation between anesthesia and antiplatelet treatment (APT)

Regional anesthesia^a		General anesthesia
Patients on APT with		Patients on APT
Acetylsalicylic acid (ASA): do not interrupt in case of secondary prevention (75–100 mg/day)	Ticlopidine—interrupt 10 days pre-op	GA always feasible
IIb/IIIa inhibitors Abciximab—RA contraindicated Eptifibatide—interrupt 8 h pre-op Tirofiban—interrupt 4 h pre-op	Clopidogrel—interrupt 7 days pre-op	Risk of surgical bleeding must always be considered before surgery

^aAPT, if no bleeding occurs, must be resumed the day following the intervention and, in the presence of epidural catheterization, after catheter removal