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Official Journal of the Italian Society of Orthopaedics and Traumatology

Table 2 Dosage and time of administration of low-molecular-weight heparin (LMHW) available in Italy

From: Italian intersociety consensus statement on antithrombotic prophylaxis in hip and knee replacement and in femoral neck fracture surgery

Active principle

Brand name

Dosage and time of administration

Enoxaparin

Clexane®

4,000 IU 12 h before surgery, then 4,000 IU/day

Nadroparin

Fraxiparine® Seleparin®

38 IU/kg 12 h before surgery and 12 h after, 38 IU/kg every 24 h during the 3 days following surgery, thereafter increasing the dose to 57 IU/kg/day

Dalteparin

Fragmin®

5,000 IU 8–12 h before surgery, then 5,000 IU/day. Alternatively 2 h, 500 IU 1–2 before surgerya and 2,500 IU 8–12 h after, thereafter either 5,000 IU/day or (only in hip surgery) 2,500 IU 4–8 h after surgery then 5,000 IU/day

Bemiparin

Ivor®

3,500 IU 6 h after surgery, then 3,500 IU/day. Alternatively 3,500 IU 2 h before surgerya, then 3,500 IU/day

Parnaparin

Fluxum®

0.4 ml (4,250 anti-Xa IU) 12 h before surgery, then 0.4 ml (4,250 anti-Xa IU)/day

Reviparin

Clivarin®

0.4 ml (4,200 anti-Xa IU) 12 h before surgery, then 0.4 ml (4,200 anti-Xa IU)/day

  1. aAlthough reported by the product label, this type of prophylaxis is not recommended