Skip to main content

Advertisement

Official Journal of the Italian Society of Orthopaedics and Traumatology

Journal of Orthopaedics and Traumatology Cover Image

Usefulness of osteoprotegerin in assessing responses to neridronate treatment in Paget's disease of bone

Abstract

Osteoprotegerin (OPG) is a protein that inhibits of osteoclastogenesis. The aim this study was to evaluate the response of serum OPG levels to neridronate treatment in patients with Paget's disease of bone resistant to previous therapy. Nine patients (4 men) affected by active Paget’s disease of bone (6 polyostotic, 3 monostotic) not responsive to clodronate were studied. Serum OPG, osteocalcin, total and bone isoenzyme of alkaline phosphatase (AP and BAP, respectively), and urinary deoxypyridinoline (DPD) were measured before and 5 months after neridronate treatment (100 mg/day, i.v. for two days). A scintigraphic activity index (SAI) was also calculated before treatment. Mean baseline OPG levels were within normal values and were not significantly different 5 months after neridronate treatment. In contrast, there were significant reductions in AP (41.9%, p<0.02) and BAP (38.8%, p<0.04). Serum OPG levels correlated with DPD (r=0.925) and SAI (r=0.689). Although OPG is an important regulator of bone metabolism, in our series of already treated patients it was not a sensitive marker for diagnosing Paget's disease and for monitoring the response to pharmacological treatment, whereas AP and BAP confirmed their clinical usefulness. This preliminary study requires confirmation by a study with a larger population.

Author information

Correspondence to F. M. Ulivieri.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ulivieri, F.M., Piodi, L.P., Marotta, G. et al. Usefulness of osteoprotegerin in assessing responses to neridronate treatment in Paget's disease of bone. J Orthopaed Traumatol 7, 192–194 (2006). https://doi.org/10.1007/s10195-006-0147-4

Download citation

Key words

  • Bone metabolism
  • Neridronate
  • Osteoprotegerin
  • Paget's disease of bone