Official Journal of the Italian Society of Orthopaedics and Traumatology
Table 2 Time to event outcomes of the study cohort after the second stage of a two-stage exchange revision for knee periprosthetic joint infection (PJI)†
Treatment outcome | All patients (n = 163) | Groups according to time to reimplantation (TTR) | p value | |
|---|---|---|---|---|
≤ 94 days (n = 104) | > 94 days (n = 59) | |||
Follow-up after stage two in months, reverse KM median (95% CI) | 38.0 (29.0–50.0) | 55.1 (38.0–62.0) | 27.0 (22.8–30.5) | 0.0002** |
Infection control | ||||
Number of events (reinfection), n | 37 | 16 | 21 | – |
HR of reinfection (95% CI) | Reference | 3.32 (1.71–6.44) | 0.0003* | |
KM est of reinfection-free rate at 2 years, % (95% CI) | 82% (74–87) | 89% (81–94) | 67% (52–79) | 0.0002** |
KM est of reinfection-free rate at 5 years, % (95% CI) | 68% (58–76) | 80% (69–87) | 33% (11–57) | |
Aseptic revision surgery after second stage | ||||
Number of events (aseptic revision), n | 21 | 16 | 5 | – |
HR of aseptic revision (95% CI) | Reference | 0.81 (0.29–2.24) | 0.6752* | |
KM est of aseptic-revision-free rate at 2 years, % (95% CI) | 91% (85–95) | 88% (79–93) | 98% (84–100) | 0.6806** |
KM est of aseptic-revision-free rate at 5 years, % (95% CI) | 76% (64–84) | 76% (62–85) | 76% (48–90) | |
Overall survival after second stage | ||||
Number of events (death), n | 28 | 17 | 11 | – |
HR of death (95% CI) | Reference | 2.17 (0.98–4.77) | 0.0622* | |
KM est of overall survival rate at 2 years after stage two, % (95% CI) | 89% (82–94) | 92% (83–96) | 85% (69–93) | 0.0494** |
KM est of overall survival rate at 5 years after stage two, % (95% CI) | 74% (63–82) | 80% (68–88) | 53% (23–76) | |