Changes in bone mineral density of the distal femur after revision total knee arthroplasty with metaphyseal press-fit stem
© The Author(s) 2010
Received: 8 December 2009
Accepted: 28 June 2010
Published: 15 July 2010
The effect of postoperative adaptive bone remodeling following a stemmed femoral implant in revision total knee arthroplasty (rTKA) is unknown. The aim of this study was to evaluate bone mineral density (BMD) changes of the distal femur following cemented rTKA with a 100-mm press-fit stem.
Materials and methods
Sixteen consecutive patients were included in the study (age range 40–85 years; mean 63.5 years). NexGen® (Zimmer, Warsaw, IN, USA) cemented revision implants were used. All implants had the same press-fit femoral stem length of 100 mm. Clinical examinations with evaluation of the knee function using the Knee Society’s Knee Scoring System were used. Measurements of BMD (g/cm2) were performed by dual-energy X-ray absorptiometry (DEXA) using a Norland XR-46 (Norland Corp. Fort Atkinson, WI, USA) bone densitometer.
Knee and function scores improved significantly (P = 0.005) from the preoperative values to 1 year of follow-up. In regions of interest (ROI) 1–4, a significant increase in BMD (3.5–6.0%) after 6 months was seen. This increase only remained significant in ROI 4 (4.0%, P = 0.01) at 1 year of follow-up.
The increase in BMD is probably the result of increased mobility and load on the extremity after implantation of a well-functioning rTKA.
KeywordsDEXA BMD Distal femur Revision total knee arthroplasty
Operation with implantation of a primary total knee arthroplasty (TKA) or a revision total knee arthroplasty (rTKA) represents a significant trauma to the bone and soft tissue of the affected extremity. It is well known that various traumatic conditions of an extremity can induce bone loss in most patients . In TKA or rTKA, other factors such as stress shielding, wear-debris-induced osteolysis, implant loosening, and bone necrosis due to infection can also play an important role in bone loss, and removal of implants during revision knee surgery can even worsen existing bone loss. Dual energy X-ray absorptiometry (DEXA) [2, 3] can be used to measure changes in bone mineral density (BMD) close to an orthopedic implant. The effect of postoperative adaptive bone remodeling with a stemmed femoral implant in rTKA is unknown. Several studies on BMD changes of the distal femur after TKA exist. A common finding is a decrease in BMD from baseline up to 2 years after operation [4–7]. No studies on BMD changes of the femur after rTKA have previously been published. The aim of this study was to evaluate BMD changes of the distal femur following cemented rTKA with a 100-mm press-fit stem.
Materials and methods
Demographic, clinical, and operative data
Body mass index
Stem length (mm)
Stem diameter (mm)
Numbers of used femur augments per patient
Cause of revision
Classification of femoral bone defects (AORI)
Changes in BMD are given as the mean percentage change together with total range and standard deviation (SD). For evaluation, t test for paired data with calculation of the 95% confidence intervals (95% CI) were performed, and P values <0.05 were considered significant.
Bone mineral density (BMD) changes in the distal tibia of the operated [revision total knee arthroplasty (rTKA)] and contralateral legs
∆ BMD (%)
∆ BMD (%)
∆ BMD (%)
−24.1 to 11.4
−17.6 to 3.3
−16.3 to 12.3
−18.5 to 12.6
−10.64 to 18.47
−16.4 to 23.7
Clinical outcome after 1 year of follow-up was comparable with other studies on rTKA with considerable bone loss, where bone loss at the proximal tibia and/or femur was reconstructed with stemmed femoral implants and impaction bone grafting [12, 13] with or without metal augments . We found at 6 months of follow-up a significant increase in BMD of 3.5–6% in all ROI along the stem. However, after 1 year, the increase (4%) in BMD was only significant in ROI 4. In ROI 5 above the stem, no significant changes in BMD were observed.
To our knowledge there exists no published studies on BMD changes at the distal femur after rTKA. Existing knowledge comes from finite element studies on stemmed femoral implants and studies evaluating changes in BMD around the femoral component without stem after TKA. In a finite element study, Van Lenthe et al.  studied bone loss and remodelling patterns of four femoral components: two primary TKAs and two stemmed revision prostheses with stem diameter of, respectively, 18 and 12 mm. They found that the revision prostheses tended to cause more bone loss than the primary implants, especially in the distal regions. They also found that prostheses with a thick press-fit stem comparable with the implants in our study would be expected to lead to an increased bone loss of the most distal femur due to increased stress shielding. However, in the ROI proximally along the stem comparable with the ROI used in this study, they found stresses and strains slightly higher than in the femur without TKA or rTKA and thus predicted minimal increase in BMD in the most proximal ROI.
Our results are consistent with the findings made by Van Lenthe et al. . We believe that the increase in BMD along the proximal parts of the femoral stem was caused by an increase in strain created by altered mechanical load. This remodelling of the periprosthetic bone is well known and is described in Wolff’s law : bone remodels and models to adapt to altered mechanical loads (adaptive bone remodeling).
Changes in bone mineral density (BMD) of the distal femur around the revision total knee arthroplasty (rTKA)
∆ BMD (%)
∆ BMD (%)
∆ BMD (%)
−5.3 to 16.4
−3.9 to 15.7
−3.4 to 10.8
−5.0 to 9.6
−4.7 to 16.1
−7.7 to 14.4
−3.3 to 5.6
−1.6 to 11.9
−9.6 to 15.0
−0.8 to 10.3
−0.7 to 10
−5.6 to 3.9
−5.3 to 3.9
−6.7 to 8.3
Studies on BMD changes at the distal femur after TKA report decreases in BMD ranging from 2.6% to 36% at 2 years of follow-up [4–7]. The bone loss is typically located behind the anterior flange of the femoral implant and reported to be caused by stress shielding. The ROI behind the anterior flange is located at the distal part of the femur, whereas the ROIs in this study are located at the more proximal parts of distal femoral shaft. Even though most studies on changes in BMD after TKA have shown loss of bone mineral with time [4–6], Petersen et al.  reported a significant increase (6,1%) in BMD at the lateral tibia condyle 2 years after TKA with uncemented tibial components without hydroxyapatite. Initial temporary increases in BMD within the first operative year after TKA were seen in another study .
Patients participating in our study all suffered from failed TKAs that resulted in periods of reduced mobilization or long-term immobilization, e.g., patients undergoing two-stage revision surgery. Given the fact that immobilization and reduced mobility suppresses BMD , the increase in BMD seen in this study is probably the result of increased mobility and load on the extremity after implantation of a well-functioning rTKA, thus stimulating femoral bone-to-bone formation.
There are some limitations to our study. The effect of canal filling could not be evaluated, as all femoral stems were in tight press fit. Furthermore, we only evaluated a femur stem length of 100-mm and thus could not measure a possible effect of the stem length on the bone remodelling pattern. In addition, the effect of pre- or preoperative femoral bone loss on the postoperative changes in BMD could not be considered, as all cases were F2b. Finally, the study included only a small sample size, which makes the results less certain, and this should be kept in mind in the interpretation of the results.
We thank laboratory technician Karen-Elisabeth Sønderlev for help with performing DEXA measurements. The DEXA scanner was donated by The Velux Foundation of 1981. Financial support was received from Maggie og Svend Fritzches Mindelegat, Zimmer, Nordic Medical Supply, and Hovedstadens Sygehusfællesskab (H:S).
Conflict of interest
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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