Official Journal of the Italian Society of Orthopaedics and Traumatology
Table 3 Self-reported VAS before and after each 4-week treatment regime
From: Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain
Pretreatment | End of 4-week treatment | P value (end of treatment versus pretreatment) | P value (drug combination versus celecoxib + placebo) | P value (drug combination versus pregabalin + placebo) | |||
|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | ||||
Celecoxib + placebo (all patients, N = 36) | 45.1 | 13.1 | 39.5 | 12.2 | 0.06 | ||
Celecoxib + placebo (LANSS <12, N = 20) | 43.8 | 12.9 | 32.5 | 15.5 | 0.01 | ||
Celecoxib + placebo (LANSS >12, N = 16) | 46.8 | 13.6 | 45.7 | 14.3 | 0.8 | ||
Pregabalin + placebo (N = 36) | 48.1 | 14.2 | 43.1 | 13.5 | 0.12 | ||
Pregabalin + placebo (LANSS <12, N = 20) | 49.4 | 13.2 | 50.7 | 13.8 | 0.76 | ||
Pregabalin + placebo (LANSS >12, N = 16) | 47.2 | 15.0 | 36.3 | 12.7 | 0.03 | ||
Celecoxib + pregabalin (all patients, N = 36) | 46.3 | 13.8 | 28.6 | 15.1 | 0.0001 | 0.001 | 0.0001 |
Celecoxib + pregabalin (LANSS <12, N = 20) | 45.1 | 14.2 | 32.9 | 13.9 | 0.009 | 0.9 | 0.0002 |
Celecoxib + pregabalin (LANSS >12, N = 16) | 47.9 | 15.2 | 23.1 | 14.6 | 0.0001 | 0.0001 | 0.01 |